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Edgar Allan Poe/Sullivan's Island Library
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Village Library
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Phone: (843) 884-9741
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Acute subjective effects in LSD- and MDMA-assisted psychotherapy.
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- Author(s): Schmid, Yasmin; Gasser, Peter; Oehen, Peter; Liechti, Matthias E
- Source:
Journal of Psychopharmacology; Apr2021, Vol. 35 Issue 4, p362-374, 13p- Subject Terms:
LSD (Drug); PSYCHOTHERAPY; POST-traumatic stress disorder; SUBSTANCE abuse; MENTAL depression; DIAGNOSIS of post-traumatic stress disorder; DIAGNOSIS of mental depression; EXPERIMENTAL design; RESEARCH; HUMAN research subjects; RESEARCH methodology; EVALUATION research; TREATMENT effectiveness; COMPARATIVE studies; DRUG monitoring; QUESTIONNAIRES; CONSCIOUSNESS disorders; ECSTASY (Drug); COMBINED modality therapy; RELIGION; HALLUCINOGENIC drugs - Source:
- Additional Information
- Subject Terms:
- Abstract:
Background: Lysergic acid diethylamide (LSD) and 3,4-methylenedioxymethamphetamine (MDMA) were used in psychotherapy in the 1960s-1980s, and are currently being re-investigated as treatments for several psychiatric disorders. In Switzerland, limited medical use of these substances is possible in patients not responding to other treatments (compassionate use).Methods: This study aimed to describe patient characteristics, treatment indications and acute alterations of mind in patients receiving LSD (100-200 µg) and/or MDMA (100-175 mg) within the Swiss compassionate use programme from 2014-2018. Acute effects were assessed using the 5 Dimensions of Altered States of Consciousness scale and the Mystical Experience Questionnaire, and compared with those in healthy volunteers administered with LSD or MDMA and patients treated alone with LSD in clinical trials.Results: Eighteen patients (including 12 women and six men, aged 29-77 years) were treated in group settings. Indications mostly included posttraumatic stress disorder and major depression. Generally, a drug-assisted session was conducted every 3.5 months after 3-10 psychotherapy sessions. LSD induced pronounced alterations of consciousness on the 5 Dimensions of Altered States of Consciousness scale, and mystical-type experiences with increases in all scales on the Mystical Experience Questionnaire. Effects were largely comparable between patients in the compassionate use programme and patients or healthy subjects treated alone in a research setting.Conclusion: LSD and MDMA are currently used medically in Switzerland mainly in patients with posttraumatic stress disorder and depression in group settings, producing similar acute responses as in research subjects. The data may serve as a basis for further controlled studies of substance-assisted psychotherapy. [ABSTRACT FROM AUTHOR] - Abstract: Copyright of Journal of Psychopharmacology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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