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Phone: (843) 766-6635
Folly Beach Library
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Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
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Wando Mount Pleasant Library
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Village Library
9 a.m. - 1 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
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Otranto Road Library
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McClellanville Library
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Keith Summey North Charleston Library
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Hurd/St. Andrews Library
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Scoping Review: Barriers and Facilitators to Enrollment in Pediatric Oncology Clinical Trials.
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- Author(s): Hauck, Cherie L. (NURSE); Cartmell, Kathleen B. (AUTHOR); Mueller, Martina (NURSE); Kelechi, Teresa J. (NURSE)
- Source:
Pediatric Nursing. Mar/Apr2021, Vol. 47 Issue 2, p79-96. 18p. 1 Diagram, 3 Charts. - Source:
- Additional Information
- Subject Terms: ONLINE information services; EXPERIMENTAL design; HEALTH policy; CLINICAL trials; HUMAN research subjects; PATIENT selection; SYSTEMATIC reviews; MOTIVATION (Psychology); ATTITUDE (Psychology); SOCIAL norms; AGE distribution; MATHEMATICAL models; MEDICAL personnel; RACE; TUMORS in children; CANCER patients; FAMILY attitudes; PATIENTS' attitudes; SEX distribution; ELIGIBILITY (Social aspects); COMMUNICATION; THEORY; LITERATURE reviews; MEDLINE; ETHNIC groups; CORPORATE culture
- Abstract: Cancer is the second-leading cause of death among children in the United States. Oncology clinical trials are designed to investigate new potential therapies. Approximately 60% of children with cancer are treated on clinical trials. The purpose of this scoping review of the literature is to explore what is known about barriers and facilitators to enrollment in pediatric oncology clinical trials. Arskey and O'Malley's (2005) methodological framework guided the scoping review. The electronic databases of PubMed and SCOPUS were searched for relevant publications. Thirty publications met eligibility criteria, which included empirical publications related to barriers and facilitators to enrollment in pediatric oncology clinical trials. Results and discussion of barriers and facilitators were organized by using a modified version of the Social Ecological Model (SEM). Trial-level barriers included lack of an available trial, trials closed to accrual, and eligibility criteria. Individual factors included age, sex, race/ethnicity, insurance status, cancer characteristics, and motivation. Interpersonal factors included parents' desire for continuity of care by health care providers, physicians' discussions with parents and children about clinical trials, and physicians' attitudes about clinical trials. Organizational factors that influenced enrollment included local availability of a clinical trial and continuity of care. No studies of community or policy-level barriers and facilitators were found. Theoretically based studies need to be conducted to identify factors at SEM levels not previously studied and investigate interventions to address factors that adversely affect enrollment. Furthermore, interdisciplinary collaboration among nurses and other professionals working at each SEM level is vital to surmount enrollment obstacles. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Pediatric Nursing is the property of Jannetti Publications, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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