Systemic Therapy for Estrogen Receptor-Positive, HER2-Negative Breast Cancer.

HORMONE receptor positive breast cancer; BREAST cancer; ESTROGEN receptors; METASTATIC breast cancer; PROGNOSIS; INSULIN-like growth factor receptors; PROTEIN metabolism; PROTEINS; SELECTIVE estrogen receptor modulators; ESTROGEN antagonists; CELL receptors; COMBINED modality therapy; BREAST tumors; CHEMICAL inhibitors

The article discusses systemic therapy for estrogen receptor- (ER-) positive, HER2-negative breast cancer. Topics include pathological and genetic features of ER-positive tumors, recommended therapy for nearly all patients with ER-positive breast cancer to prevent metastatic disease, local-regional recurrence, and contralateral tumors, and important regulators of cell-cycle progression in many cell types, including ER-positive breast cancer.