Validation of capillary glucose measurements to detect glucose intolerance or type 2 diabetes mellitus in the general population.

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  • Author(s): Kruijshoop M;Kruijshoop M; Feskens EJ; Blaak EE; de Bruin TW
  • Source:
    Clinica chimica acta; international journal of clinical chemistry [Clin Chim Acta] 2004 Mar; Vol. 341 (1-2), pp. 33-40.
  • Publication Type:
    Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 1302422 Publication Model: Print Cited Medium: Print ISSN: 0009-8981 (Print) Linking ISSN: 00098981 NLM ISO Abbreviation: Clin Chim Acta Subsets: MEDLINE
    • Publication Information:
      Original Publication: Amsterdam, Elsevier.
    • Subject Terms:
      Blood Glucose/*metabolism ; Diabetes Mellitus, Type 2/*diagnosis ; Glucose Intolerance/*diagnosis; Aged ; Blood Glucose/analysis ; Capillaries/metabolism ; Cohort Studies ; Fasting/metabolism ; Female ; Glucose Tolerance Test ; Humans ; Male ; Middle Aged ; Netherlands ; Population ; Prospective Studies ; Reference Values ; Reproducibility of Results
    • Abstract:
      Background: The use of an oral glucose tolerance test (OGTT) has been recommended to diagnose type 2 diabetes, but an OGTT with venous blood sampling may not be feasible in the screening phase preceding large epidemiological studies. We have conducted a population-based screening in 2715 men and women and evaluated the diagnostic validity of capillary plasma glucose concentration measurements versus venous plasma glucose concentration measurements in a subset of 350 subjects.
      Methods: During a single OGTT, glucose concentrations were measured in venous plasma as well as in capillary plasma.
      Results: Based on the 1999 WHO criteria for venous glucose concentrations, the study population (n=350) yielded 97 subjects with type 2 diabetes mellitus, 77 subjects with impaired glucose tolerance and 176 subjects with normal glucose tolerance. Sensitivity and specificity to diagnose type 2 diabetes mellitus by capillary plasma were 84% and 98%, respectively. Consistent classification by either venous or capillary plasma glucose measurements was 78% (kappa=0.65, p<0.001).
      Conclusion: Capillary glucose measurements are suitable for use in epidemiological studies to diagnose and detect type 2 diabetes and normal glucose tolerance. Use of capillary measurements can result in cost-effective inclusion schemes in epidemiological studies.
    • Accession Number:
      0 (Blood Glucose)
    • Publication Date:
      Date Created: 20040218 Date Completed: 20040706 Latest Revision: 20220318
    • Publication Date:
      20231215
    • Accession Number:
      10.1016/j.cccn.2003.10.033
    • Accession Number:
      14967156