[Bile acids in the process of canalicular bile formation].

Zhovchni kysloty v protsesakh utvorennia kanal'tsevoï zhovchi.

Publisher: Naukova Dumka Country of Publication: Ukraine NLM ID: 9601541 Publication Model: Print Cited Medium: Print ISSN: 2522-9028 (Print) Linking ISSN: 25229028 NLM ISO Abbreviation: Fiziol Zh (1994) Subsets: MEDLINE

Publication: Kyiv : Naukova Dumka
Original Publication: Kyïv : Nauk. dumka, 1994-

Bile/*metabolism ; Bile Acids and Salts/*metabolism ; Bile Canaliculi/*metabolism ; Hepatocytes/*metabolism; Animals ; Apoptosis ; Bile/chemistry ; Bile Canaliculi/cytology ; Biological Transport, Active ; Cholestasis/etiology ; Cholestasis/genetics ; Cholestasis/metabolism ; Gene Expression Regulation ; Hepatocytes/pathology ; Humans ; Hydrophobic and Hydrophilic Interactions ; Membrane Transport Proteins/genetics ; Membrane Transport Proteins/metabolism ; Necrosis ; Ursodeoxycholic Acid/metabolism

This review summarizes the current knowledge of the role of bile acid in the canalicular bile secretion: its membrane transport in hepatocyte; molecular mechanisms and pathways of its regulatory effects on membrane transporters; the role of its hydrophobicity in membrane transporter regulation; hepatocyte necrosis and apoptosis at cholestasis induced by hydrophobic bile acids; the possible mechanisms of protective effects of ursodeoxycholic acid in cholestatic impairment of the liver.

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0 (Bile Acids and Salts)
0 (Membrane Transport Proteins)
724L30Y2QR (Ursodeoxycholic Acid)

Date Created: 20040218 Date Completed: 20040416 Latest Revision: 20181130

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