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John L. Dart Library
9 a.m. - 6 p.m.
Phone: (843) 722-7550
West Ashley Library
9 a.m. - 6 p.m.
Phone: (843) 766-6635
Folly Beach Library
9 a.m. - 1 p.m.
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
Wando Mount Pleasant Library
9 a.m. - 6 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 6 p.m.
Phone: (843) 889-3300
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9 a.m. - 6 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
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Keith Summey North Charleston Library
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John's Island Library
9 a.m. - 6 p.m.
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Phone: (843) 795-6679
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Phone: (843) 805-6930
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A prospective single‐institution study of intraoperative radiotherapy (IORT) for early‐stage breast cancer.
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- Author(s): Nguyen, My‐Lien; Pius, Patricia; Dooley, William; Squires, Ronald; Algan, Ozer; Chen, Yong; Johnson, Daniel; Henson, Christina
- Source:
Breast Journal. Mar2021, Vol. 27 Issue 3, p231-236. 6p. - Source:
- Additional Information
- Subject Terms:
- Subject Terms:
- Abstract: Intraoperative radiation therapy (IORT) is an option for breast‐conserving therapy in early‐stage breast cancer. IORT is given in one fraction at the time of surgery and eliminates the need for adjuvant external beam radiation therapy. However, previous trials indicate increased local failure rates compared with whole‐breast irradiation, which engenders controversy around the appropriate use of IORT. We conducted a prospective study of patients diagnosed with early‐stage breast cancer (T1‐T2, N0‐N1) at the University of Oklahoma Health Sciences Center (OUHSC) between 2013 and 2017 and treated with lumpectomy followed by intraoperative radiation therapy (IORT). Data collected included stage of disease, tumor location, histology, tumor markers, lymph node status, surgical margin size, recurrence, cosmetic outcomes, and length of follow‐up. In‐breast tumor recurrence rate (IBTR) in the 77 evaluable patients was 3.9% (3 patients). Margins were close (1 mm or less) in all three recurrent patients, and two were initially diagnosed with DCIS. Recurrence rates in our patients were comparable to prior reports. All recurrences were in patients with close margins indicating that this may represent a predictive feature for exclusion from IORT; additional studies are essential to determine the recurrence rates among patients treated with IORT and to identify potential predictors of IORT eligibility. [ABSTRACT FROM AUTHOR]
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