[A screening method for rapid detection of barbiturates in serum using tandem mass spectrometry].

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  • Author(s): Bold P;Bold P; Brzezinka H; Budzikiewicz H
  • Source:
    Beitrage zur gerichtlichen Medizin [Beitr Gerichtl Med] 1992; Vol. 50, pp. 99-104.
  • Publication Type:
    English Abstract; Journal Article
  • Language:
    German
  • Additional Information
    • Transliterated Title:
      Eine Screening-Methode zum schnellen Nachweis von Barbituraten im Serum mittels Tandem-Massenspektrometrie.
    • Source:
      Publisher: Verlag Franz Deuticke Country of Publication: Austria NLM ID: 0400646 Publication Model: Print Cited Medium: Print ISSN: 0067-5016 (Print) Linking ISSN: 00675016 NLM ISO Abbreviation: Beitr Gerichtl Med Subsets: MEDLINE
    • Publication Information:
      Publication: Vienna : Verlag Franz Deuticke
      Original Publication: Wien [etc.]
    • Subject Terms:
      Barbiturates/*pharmacokinetics; Humans ; Mass Spectrometry ; Pentobarbital/pharmacokinetics ; Phenobarbital/pharmacokinetics
    • Abstract:
      A mass spectrometric screening method for the detection of barbiturates in serum will be presented. Fragmentation of barbiturates under EI conditions leads to a loss of HNCO. Therefore, "neutral loss scans" of 43 u allow the indication of possibly existing representatives of this class of compounds. Identification can be achieved by "daughter" or "parent ion scans". Thus, 10 micrograms/ml apro-, pento- and phenobarbital could be detected in serum.
    • Accession Number:
      0 (Barbiturates)
      I4744080IR (Pentobarbital)
      Q0YKG9L6RF (allylpropymal)
      YQE403BP4D (Phenobarbital)
    • Publication Date:
      Date Created: 19920101 Date Completed: 19930223 Latest Revision: 20131121
    • Publication Date:
      20250114
    • Accession Number:
      1489359