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9 a.m. – 7 p.m.
Phone: (843) 722-7550
West Ashley Library
9 a.m. – 7 p.m.
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Folly Beach Library
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Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
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Phone: (843) 883-3914
Wando Mount Pleasant Library
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Village Library
9 a.m. – 6 p.m.
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McClellanville Library
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John's Island Library
9 a.m. – 8 p.m.
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Normalization and the Search for Variation in the Human Genome.
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- Author(s): DE CHADAREVIAN, SORAYA
- Source:
Historical Studies in the Natural Sciences; Nov2020, Vol. 50 Issue 5, p578-595, 18p- Subject Terms:
- Source:
- Additional Information
- Abstract: This essay reflects on the tension between standardization and the search for variation in the human genome. The stabilization of the human chromosome count in the 1920s was based on the consensus that "Whites," "Negroes," and "Japanese," as well as women and men, had the same number of chromosomes. Yet the idea that there might be chromosomal differences between various groups of people was never quite abandoned. When in the mid-1950s the human chromosome number was revised from 48 to 46, the new count was tested in populations around the world. The description of the "normal human karyotype" that was negotiated in the 1960s was driven by the search for a standard against which the genetic variation revealed by the flurry of testing could be measured. And although the human genome project in the 1990s promised to provide the genetic blueprint that all humans shared, it has in fact led to an increased focus on the genetic variation that distinguishes the history, identity, and health outcomes of various human populations. Following concrete examples, this essay investigates the historically contingent quests that have been driving the search for common standards and variation, and the role Pacific and Indigenous populations have played in these endeavors. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Historical Studies in the Natural Sciences is the property of University of California Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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