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Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
West Ashley Library
9 a.m. – 7 p.m.
Phone: (843) 766-6635
Wando Mount Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. – 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. – 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. – 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 6 p.m.
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Keith Summey North Charleston Library
9 a.m. – 8 p.m.
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John's Island Library
9 a.m. – 8 p.m.
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Hurd/St. Andrews Library
9 a.m. – 8 p.m.
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Miss Jane's Building (Edisto Library Temporary Location)
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Dorchester Road Library
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Phone: (843) 552-6466
John L. Dart Library
9 a.m. – 7 p.m.
Phone: (843) 722-7550
Baxter-Patrick James Island
9 a.m. – 8 p.m.
Phone: (843) 795-6679
Main Library
9 a.m. – 8 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
9 a.m. – 8 p.m.
Phone: (843) 805-6892
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
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Toddler With New Onset Diabetes and Atypical Hemolytic-Uremic Syndrome in the Setting of COVID-19.
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- Author(s): Alizadeh, Faraz; O'Halloran, Amanda; Alghamdi, Areej; Chen, Charlotte; Trissal, Maria; Traum, Avram; DeCourcey, Danielle
- Source:
Pediatrics. Feb2021, Vol. 147 Issue 2, p1-6. 6p. - Source:
- Additional Information
- Subject Terms: INSULIN therapy; THERAPEUTIC use of monoclonal antibodies; ACID-base equilibrium; BLOOD sugar; CALCITONIN; DIABETES; DIABETIC acidosis; DIFFERENTIAL diagnosis; DISSEMINATED intravascular coagulation; FEVER; FLUID therapy; HEMOLYTIC-uremic syndrome; HYPERNATREMIA; IMMUNOGLOBULINS; INSULIN; POLYMERASE chain reaction; TACHYCARDIA; THROMBOTIC thrombocytopenic purpura; 3-Hydroxybutyric acid; TACHYPNEA; COVID-19; CHILDREN
- Abstract: This is a novel case of a 16-month-old boy with a history of prematurity with intrauterine growth restriction, severe failure to thrive, microcephaly, pachygyria, agenesis of the corpus callosum, and postnatal embolic stroke, who presented with new-onset diabetes mellitus with diabetic ketoacidosis in the setting of severe acute respiratory syndrome coronavirus 2 infection, with a course complicated by atypical hemolytic syndrome (aHUS). This patient demonstrated remarkable insulin resistance in the period before aHUS diagnosis, which resolved with the first dose of eculizumab therapy. There is increasing evidence that COVID-19 is associated with thrombotic disorders and that microangiopathic processes and complement-mediated inflammation may be implicated. In this case report, we describe a pediatric patient with COVID-19 and a new complement-mediated microangiopathic thrombotic disease. Because whole-exome sequencing and extensive workup returned without a clear etiology for aHUS, this is likely a COVID-19 triggered case of aHUS versus an idiopathic case that was unmasked by the infection. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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