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West Ashley Library
9 a.m. - 7 p.m.
Phone: (843) 766-6635
Folly Beach Library
9 a.m. - 5:30 p.m.
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Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
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Wando Mount Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
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Development of a coronavirus disease 2019 nonhuman primate model using airborne exposure.
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- Author(s): Johnston, Sara C.1 (AUTHOR) ; Ricks, Keersten M.2 (AUTHOR); Jay, Alexandra3 (AUTHOR); Raymond, Jo Lynne4 (AUTHOR); Rossi, Franco3 (AUTHOR); Zeng, Xiankun4 (AUTHOR); Scruggs, Jennifer4 (AUTHOR); Dyer, David3 (AUTHOR); Frick, Ondraya3 (AUTHOR); Koehler, Jeffrey W.2 (AUTHOR); Kuehnert, Paul A.2 (AUTHOR); Clements, Tamara L.2 (AUTHOR); Shoemaker, Charles J.2 (AUTHOR); Coyne, Susan R.2 (AUTHOR); Delp, Korey L.2 (AUTHOR); Moore, Joshua3 (AUTHOR); Berrier, Kerry3 (AUTHOR); Esham, Heather3 (AUTHOR); Shamblin, Joshua3 (AUTHOR); Sifford, Willie3 (AUTHOR)
- Source:
PLoS ONE. 2/2/2021, Vol. 16 Issue 2, p1-25. 25p.- Subject Terms:
- Source:
- Additional Information
- Abstract: Airborne transmission is predicted to be a prevalent route of human exposure with SARS-CoV-2. Aside from African green monkeys, nonhuman primate models that replicate airborne transmission of SARS-CoV-2 have not been investigated. A comparative evaluation of COVID-19 in African green monkeys, rhesus macaques, and cynomolgus macaques following airborne exposure to SARS-CoV-2 was performed to determine critical disease parameters associated with disease progression, and establish correlations between primate and human COVID-19. Respiratory abnormalities and viral shedding were noted for all animals, indicating successful infection. Cynomolgus macaques developed fever, and thrombocytopenia was measured for African green monkeys and rhesus macaques. Type II pneumocyte hyperplasia and alveolar fibrosis were more frequently observed in lung tissue from cynomolgus macaques and African green monkeys. The data indicate that, in addition to African green monkeys, macaques can be successfully infected by airborne SARS-CoV-2, providing viable macaque natural transmission models for medical countermeasure evaluation. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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