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Main Library
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Wando Mount Pleasant Library
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Folly Beach Library
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Miss Jane's Building (Edisto Library Temporary Location)
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John L. Dart Library
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St. Paul's/Hollywood Library
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Mt. Pleasant Library
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John's Island Library
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Bcl‐3 inhibits lupus‐like phenotypes in BL6/lpr mice.
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![loading](/sites/all/modules/hf_eds/images/loading.gif)
- Author(s): Tang, Wanhu; Wang, Hongshan; Tian, Ruxiao; Saret, Sun; Cheon, HeeJin; Claudio, Estefania; Siebenlist, Ulrich
- Source:
European Journal of Immunology; Jan2021, Vol. 51 Issue 1, p197-205, 9p- Subject Terms:
- Source:
- Additional Information
- Subject Terms:
- Abstract: Bcl‐3 is an atypical member of the IκB family that modulates NF‐κB activity in nuclei. lpr mice carry the lpr mutation in Fas, resulting in functional loss of this death receptor; they serve as models for lupus erythematosus and autoimmune lymphoproliferation syndrome (ALPS). To explore the biologic roles of Bcl‐3 in this disease model, we generated BL6/lpr mice lacking Bcl‐3. Unlike lpr mice on an MRL background, BL6/lpr mice present with very mild lupus‐ or ALPS‐like phenotypes. Bcl‐3 KO BL6/lpr mice, however, developed severe splenomegaly, dramatically increased numbers of double negative T cells — a hallmark of human lupus, ALPS, and MRL/lpr mice — and exhibited inflammation in multiple organs, despite low levels of autoantibodies, similar to those in BL6/lpr mice. Loss of Bcl‐3 specifically in T cells exacerbated select lupus‐like phenotypes, specifically organ infiltration. Mechanistically, elevated levels of Tnfα in Bcl‐3 KO BL6/lpr mice may promote lupus‐like phenotypes, since loss of Tnfα in these mice reversed the pathology due to loss of Bcl‐3. Contrary to the inhibitory functions of Bcl‐3 revealed here, this regulator has also been shown to promote inflammation in different settings. Our findings highlight the profound, yet highly context‐dependent roles of Bcl‐3 in the development of inflammation‐associated pathology. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of European Journal of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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