Abstract: The genus Salvia L. (Lamiaceae) comprises about 900 species widespread throughout the world. Salvia sclarea L., Clary Sage, one of the most appreciated representative of genus Salvia, is a biennial dicot shrub, native to southern Europe regions, but cultivated all over the world as a source of essential oil. Long history of use as a traditional medicine (antiseptic, anti-inflammatory, stomachic, digestive etc.) is further supported in the numerous scientific studies (Foray et al., 1999; Pitarokili et al., 2002). Evaluation of secondary metabolism rate, modification in the qualities and quantities of essential oil constituents, and in particular the principal active ones affecting the biological activities is fundamental (Hudaib et al., 2001). The chemical composition of the essential oil of S. sclarea was found to be highly influenced by genetic and environmental factors, organ age, climate conditions, and seasonality. Herein, we present the results of detailed analyses of the essential oil constituents of the commercial sample of S. sclarea aerial parts. Plant material, harvested at full flowering stage from southeastern Serbian regions, yielded a transparent, yellowish fragrant essential oil. Subsequent meticulous GC and GC-MS analyses enabled the identification of more than 60 constituents, among which linalyl acetate (43.17%), linalool (15.8%), germacrene D (9.73%), caryophyllene (5.13%) and sclareol (1.43%) were the dominant ones. Together with the secondary metabolite profile, determination of the Serbian S. sclarea essential oil agricultural plant protection potential was estimated by assessing sporulation intensity and mycelia growth of Colletotrichum acutatum J.H. Simmonds C.A.2 isolates, causative of strawberry antrachnose, in vitro. [ABSTRACT FROM AUTHOR]
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