Fasting plasma glucose and glycated haemoglobin in the screening of diabetes and impaired glucose tolerance.

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  • Additional Information
    • Source:
      Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9200299 Publication Model: Print Cited Medium: Print ISSN: 0940-5429 (Print) Linking ISSN: 09405429 NLM ISO Abbreviation: Acta Diabetol Subsets: MEDLINE
    • Publication Information:
      Publication: Berlin : Springer Verlag
      Original Publication: Berlin : Springer International, c1991-
    • Subject Terms:
      Fasting*; Blood Glucose/*metabolism ; Diabetes Mellitus/*diagnosis ; Glucose Intolerance/*diagnosis ; Glycated Hemoglobin/*analysis; Adult ; Aged ; Blood Glucose/analysis ; Diabetes Mellitus/blood ; Diabetes Mellitus/epidemiology ; Female ; France/epidemiology ; Glucose Intolerance/blood ; Glucose Tolerance Test ; Humans ; Male ; Mass Screening/methods ; Middle Aged ; Obesity ; ROC Curve ; Reproducibility of Results ; Sensitivity and Specificity ; Sex Characteristics
    • Abstract:
      The use of fasting plasma glucose (FPG) only has been proposed for the screening and diagnosis of diabetes, but its sensitivity has been reported to be unsatisfactory. The use of HbA1C, alone or combined with FPG, has been suggested for the screening of diabetes and impaired glucose tolerance (IGT). In a sample of 1215 adult subjects without previously known diabetes, we assessed the sensitivity and specificity of FPG and HbA1C in diagnosing diabetes and IGT, determined by oral glucose tolerance test (OGTT). All lean diabetic patients, and 85% of overweight and obese diabetic individuals, had FPG > or =7 mmol/l. FPG >6.1 mmol/l had a sensitivity of 98.8% and a specificity of 32.9%; HbA1C had a lower specificity and sensitivity for the screening of diabetes. A screening strategy for diabetes based on FPG, with OGTT in all overweight subjects with FPG >6.1 mmol/l, is suggested. Neither FPG nor HbA1C is effective in the screening of IGT; although combined FPG and HbA1C could be useful for case finding, screening for IGT with OGTT is advisable in all subjects at high risk.
    • Accession Number:
      0 (Blood Glucose)
      0 (Glycated Hemoglobin A)
    • Publication Date:
      Date Created: 20040124 Date Completed: 20040305 Latest Revision: 20221207
    • Publication Date:
      20221213
    • Accession Number:
      10.1007/s00592-003-0109-8
    • Accession Number:
      14740278