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John L. Dart Library
Closed for Maintenance
Phone: (843) 722-7550
West Ashley Library
9 a.m. - 5 p.m.
Phone: (843) 766-6635
Folly Beach Library
9 a.m. - 2 p.m.
*open the 2nd and 4th Saturday
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Edgar Allan Poe/Sullivan's Island Library
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Wando Mount Pleasant Library
9 a.m. - 5 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 1 p.m.
Phone: (843) 884-9741
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Longitudinal In-Vivo X-Ray Fluorescence Computed Tomography With Molybdenum Nanoparticles.
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- Author(s): Shaker, Kian1 (AUTHOR) ; Vogt, Carmen1 (AUTHOR) ; Katsu-Jimenez, Yurika2 (AUTHOR) ; Kuiper, Raoul V.3 (AUTHOR) ; Andersson, Kenth1 (AUTHOR) ; Li, Yuyang1 (AUTHOR) ; Larsson, Jakob C.1 (AUTHOR) ; Rodriguez-Garcia, Aida2 (AUTHOR) ; Toprak, Muhammet S.1 (AUTHOR) ; Arsenian-Henriksson, Marie2 (AUTHOR) ; Hertz, Hans M.1 (AUTHOR)
- Source:
IEEE Transactions on Medical Imaging. Dec2020, Vol. 39 Issue 12, p3910-3919. 10p.- Subject Terms:
- Source:
- Additional Information
- Abstract: X-ray fluorescence computed tomography (XFCT) with nanoparticles (NPs) as contrast agents shows potential for molecular biomedical imaging with higher spatial resolution than present methods. To date the technique has been demonstrated on phantoms and mice, however, parameters such as radiation dose, exposure times and sensitivity have not yet allowed for high-spatial-resolution in vivo longitudinal imaging, i.e., imaging of the same animal at different time points. Here we show in vivo XFCT with spatial resolution in the 200- $400~\boldsymbol {\mu }\text{m}$ range in a proof-of-principle longitudinal study where mice are imaged five times each during an eight-week period following tail-vein injection of NPs. We rely on a 24 keV x-ray pencil-beam-based excitation of in-house-synthesized molybdenum oxide NPs (MoO2) to provide the high signal-to-background x-ray fluorescence detection necessary for XFCT imaging with low radiation dose and short exposure times. We quantify the uptake and clearance of NPs in vivo through imaging, and monitor animal well-being over the course of the study with support from histology and DNA stability analysis to assess the impact of x-ray exposure and NPs on animal welfare. We conclude that the presented imaging arrangement has potential for in vivo longitudinal studies, putting emphasis on designing biocompatible NPs as the future focus for active-targeting preclinical XFCT. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of IEEE Transactions on Medical Imaging is the property of IEEE and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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