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Correlación de los valores de vitamina D con los de hormona antimülleriana en mujeres con infertilidad. (Spanish)
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- Author(s): Garza-Garza, Mario Alberto; Aguilar-Melgar, Ashanti Edith; Dávila Garza, Sergio Alberto; Galache-Vega, Pedro; Santos-Haliscak, Roberto
- Source:
Ginecología y Obstetricia de México; dic2020, Vol. 88 Issue 12, p833-838, 6p- Subject Terms:
- Source:
- Additional Information
- Alternate Title: Correlation of vitamin D values with those of anti-Müllerian hormone in infertile women. (English)
- Abstract: OBJECTIVE: To evaluate the association between serum concentrations of 25-hydroxyvitamin D and antimullerian hormone in Mexican patients with infertility. MATERIALS AND METHODS: Retrospective, cross-sectional study of relational analysis of patients who came to consult at the IECH Fertility Center between the months of May 2019 and May 2020. The Kolmogorov-Smirnov normality test was used, with means and standard deviations (SD) for normal values; medians and interquantity ranges (IQR) for non-parametric values. To show differences between the groups the paired t-test and Mann-Whitney test were applied depending, respectively, on the normality of the data and the Spearman correlation coefficient to calculate the dependence between non-parametric variables. GraphPad Prism (v 8) was used, the value of p < 0.05 was considered with statistical significance. RESULTS: A total of 106 files of patients diagnosed with infertility with a mean age of 35 4.97 and a median of 19.90 ng/mL (IQR 57.06) of 25-hydroxyvitamin D were analyzed. Vitamin D deficiency (less than 20 ng/mL) was not associated with antimullerian hormone values (p = 0.0525); a difference was found between vitamin D concentrations for patients younger and older than 35 years (p = 0.0423) and a correlation between vitamin D and antimullerian hormone (Spearman's rho: -0.210, 95%CI -0.41 to -0.005, p = 0.0495). CONCLUSIONS: 50% of the infertile patients had vitamin D deficiency. Although the mechanism is not properly elucidated, there is a dependence on the values of 25-hydroxyvitamin D and the antimullerian hormone. [ABSTRACT FROM AUTHOR]
- Abstract: OBJETIVO: Evaluar la asociación entre las concentraciones séricas de 25-hidroxivitamina D y las de hormona antimülleriana en pacientes mexicanas con infertilidad. MATERIALES Y MÉTODOS: Estudio retrospectivo, transversal, de análisis relacional de pacientes que acudieron a consulta al Centro de Fertilidad-IECH entre los meses de mayo de 2019 y mayo de 2020. Se utilizó la prueba de normalidad de Kolmogorov-Smirnov, con medias y desviaciones estándar para valores normales; medianas y rangos intercuartiles (RIQ) para valores no paramétricos. Para mostrar diferencias entre los grupos se aplicó la prueba t pareada y de Mann-Whitney dependiendo, respectivamente, de la normalidad de los datos y del coeficiente de correlación de Spearman para calcular la dependencia entre las variables no paramétricas. Se usó el programa GraphPad Prism (v 8), el valor de p < 0.05 se consideró con significación estadística. RESULTADOS: Se analizaron 106 expedientes de pacientes con diagnóstico de infertilidad con media de 35 ± 4.97 años y mediana de 19.90 ng/mL (RIQ 57.06) de 25-hidroxivitamina D. La deficiencia de vitamina D (menos de 20 ng/mL) no se asoció con los valores de hormona antimülleriana (p = 0.0525); se encontró diferencia entre las concentraciones de vitamina D para pacientes menores y mayores de 35 años (p = 0.0423) y una correlación entre vitamina D y hormona antimülleriana (rho de Spearman: -0.210, IC95%: -0.41 a -0.005, p = 0.0495). CONCLUSIONES: El 50% de las pacientes infértiles tenía deficiencia de vitamina D. Si bien no está debidamente dilucidado el mecanismo, existe una dependencia de los valores de 25-hidroxivitamina D y de la hormona antimülleriana. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Ginecología y Obstetricia de México is the property of Federacion Mexicana de Ginecologia y Obstetricia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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