Evidence of TCM Theory in Treating the Same Disease with Different Methods: Treatment of Pneumonia with Ephedra sinica and Scutellariae Radix as an Example.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read Online Read More Add to Saved list
  • Author(s): Sun, Liping (AUTHOR); Wang, Dandan (AUTHOR); Xu, Yan (AUTHOR); Qi, Wenxiu (AUTHOR); Wang, Yanbo (AUTHOR)
  • Source:
    Evidence-based Complementary & Alternative Medicine (eCAM). 11/28/2020, p1-23. 23p. 2 Color Photographs, 6 Diagrams, 3 Charts, 1 Graph.
  • Additional Information
    • Subject Terms:
      ANTIBIOTICS; THERAPEUTIC use of ephedra; THERAPEUTIC use of plant extracts; APOPTOSIS; CELLULAR signal transduction; COLD therapy; INTERLEUKINS; MATHEMATICAL models; CHINESE medicine; PHARMACOLOGY; PNEUMONIA; THERMOTHERAPY; THEORY; TREATMENT effectiveness; MOLECULAR dynamics; MOLECULAR docking
    • Abstract:
      Pneumonia is a serious global health problem and the leading cause of mortality in children. Antibiotics are the main treatment for bacterial pneumonia, but there are serious drug resistance problems. Traditional Chinese medicine (TCM) has been used to treat diseases for thousands of years and has a unique theory. This article takes the treatment of pneumonia with Ephedra sinica as a representative hot medicine and Scutellariae Radix as a representative cold medicine as an example. We explore and explain the theory of treating the same disease with different TCM treatments. Using transcriptomics and network pharmacology methods, GO, KEGG enrichment, and PPI network construction were carried out, demonstrating that Ephedra sinica plays a therapeutic role through the NF-κB and apoptosis signaling pathways targeting PLAU, CD40LG, BLC2L1, CASP7, and CXCL8. The targets of Scutellariae Radix through the IL-17 signaling pathway are MMP9, CXCL8, and MAPK14. Molecular docking technology was also used to verify the results. In short, our results provide evidence for the theory of treating the same disease with different treatments, and we also discuss future directions for traditional Chinese medicine. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Evidence-based Complementary & Alternative Medicine (eCAM) is the property of Hindawi Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)