Activity of dorsal raphe cells across the sleep-waking cycle and during cataplexy in narcoleptic dogs.

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  • Author(s): Wu MF;Wu MF; John J; Boehmer LN; Yau D; Nguyen GB; Siegel JM
  • Source:
    The Journal of physiology [J Physiol] 2004 Jan 01; Vol. 554 (Pt 1), pp. 202-15.
  • Publication Type:
    Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Cambridge Univ. Press Country of Publication: England NLM ID: 0266262 Publication Model: Print Cited Medium: Print ISSN: 0022-3751 (Print) Linking ISSN: 00223751 NLM ISO Abbreviation: J Physiol Subsets: MEDLINE
    • Publication Information:
      Publication: Oxford : Blackwell : Cambridge Univ. Press
      Original Publication: London, Cambridge Univ. Press.
    • Subject Terms:
      Cataplexy/*physiopathology ; Raphe Nuclei/*physiology ; Sleep, REM/*physiology ; Wakefulness/*physiology; Action Potentials/physiology ; Animals ; Dogs ; Electroencephalography ; Neurons/chemistry ; Neurons/physiology ; Raphe Nuclei/cytology ; Serotonin/analysis
    • Abstract:
      Cataplexy, a symptom associated with narcolepsy, represents a unique dissociation of behavioural states. During cataplectic attacks, awareness of the environment is maintained, as in waking, but muscle tone is lost, as in REM sleep. We have previously reported that, in the narcoleptic dog, noradrenergic cells of the locus coeruleus cease discharge during cataplexy. In the current study, we report on the activity of serotonergic cells of the dorsal raphe nucleus. The discharge patterns of serotonergic dorsal raphe cells across sleep-waking states did not differ from those of dorsal raphe and locus coeruleus cells recorded in normal rats, cats and monkeys, with tonic discharge in waking, reduced activity in non-REM sleep and cessation of activity in REM sleep. However, in contrast with locus coeruleus cells, dorsal raphe REM sleep-off neurones did not cease discharge during cataplexy. Instead, discharge continued at a level significantly higher than that seen in REM sleep and comparable to that seen in non-REM sleep. We also identified several cells in the dorsal raphe whose pattern of activity was the opposite of that of the presumed serotonergic cells. These cells were maximally active in REM sleep and minimally active in waking and increased activity during cataplexy. The difference between noradrenergic and serotonergic cell discharge profiles in cataplexy suggests different roles for these cell groups in the normal regulation of environmental awareness and muscle tone and in the pathophysiology of narcolepsy.
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    • Grant Information:
      R37 HL041370 United States HL NHLBI NIH HHS; R01 NS014610 United States NS NINDS NIH HHS; HL41370 United States HL NHLBI NIH HHS; NS14610 United States NS NINDS NIH HHS; R01 MH064109 United States MH NIMH NIH HHS; R37 NS014610 United States NS NINDS NIH HHS; MH64109 United States MH NIMH NIH HHS; R01 HL041370 United States HL NHLBI NIH HHS
    • Accession Number:
      333DO1RDJY (Serotonin)
    • Publication Date:
      Date Created: 20031218 Date Completed: 20040406 Latest Revision: 20181113
    • Publication Date:
      20240829
    • Accession Number:
      PMC1664742
    • Accession Number:
      10.1113/jphysiol.2003.052134
    • Accession Number:
      14678502