Sinapic acid safeguards cardiac mitochondria from damage in isoproterenol‐induced myocardial infarcted rats.

Myocardial infarction (MI) is a life‐threatening disease. In this study, we examined the anti‐mitochondrial damaging effects of sinapic acid (SA) in isoproterenol (ISO)‐induced myocardial infarcted rats. Myocardial infarcted rats were prepared by injecting ISO (100 mg/kg body weight) on the 9th and 10th day. Rats were pretreated and cotreated with SA (12 mg/kg body weight) orally, daily for 10 days. A considerable increase in serum lactate dehydrogenase, creatine kinase, myoglobin, and cardiac troponin‐T was noticed in the ISO‐induced rats. ISO also significantly amplified lipid peroxidation and calcium ions, and depleted the antioxidant system and mitochondrial enzymes in rat's heart mitochondria. SA treatment improved the distorted above‐ mentioned biochemical parameters in ISO‐treated rats with its anti‐mitochondrial damaging effects. This ultrastructural study on heart mitochondria and in vitro studies also confirmed the effects of SA. The current findings are suggestive of SA's cardioprotective effects. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Biochemical & Molecular Toxicology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)