[Evaluation of intraarterial infusion chemotherapy for liver metastasis from gastric cancer FEM: combination therapy of 5-FU, epirubicin and MMC].

Publisher: Gan To Kagaku Ryohosha Country of Publication: Japan NLM ID: 7810034 Publication Model: Print Cited Medium: Print ISSN: 0385-0684 (Print) Linking ISSN: 03850684 NLM ISO Abbreviation: Gan To Kagaku Ryoho Subsets: MEDLINE

Publication: Tokyo : Gan To Kagaku Ryohosha
Original Publication: Tōkyō, Gan to Kagaku Ryōhōsha [1974?]-

Antineoplastic Combined Chemotherapy Protocols/*therapeutic use ; Liver Neoplasms/*drug therapy ; Liver Neoplasms/*secondary ; Stomach Neoplasms/*pathology; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Drug Administration Schedule ; Epirubicin/administration & dosage ; Female ; Fluorouracil/administration & dosage ; Gastrectomy ; Hepatectomy ; Hepatic Artery ; Humans ; Infusions, Intra-Arterial ; Liver Neoplasms/mortality ; Liver Neoplasms/surgery ; Male ; Middle Aged ; Mitomycin/administration & dosage ; Stomach Neoplasms/mortality ; Stomach Neoplasms/surgery ; Survival Rate

Objective: We evaluated the effectiveness of FEM (5-FU, epirubicin, MMC) therapy.
Subjects: Data for 111 patients with liver metastasis from gastric cancer were collected from January 1977, until June 2003 (synchronous: 74 cases, asynchronous: 37 cases). Thirty patients were H1, 20 were H2 and 61 were classified as H3.
Methods: The patients were divided into the following groups: Group A: Resection of the primary lesion and hepatic resection (n = 10), Group A1: Hepatic resection only (5 cases), Group A2: Hepatic resection and intraarterial infusion (5 cases). Group B: Resection of the primary lesion (n = 67), Group B1: Resection of the primary lesion only (46 cases), Group B2: Intraarterial infusion (21 cases). In Groups A2 and B2, FEM therapy was applied to A2a (4 cases) and B2a (8 cases). Non-FEM therapy was applied to A2b (1 case) and B2b (13 cases). Group C consisted of 34 cases in which resection of the primary lesion was not undertaken. Survival rates were then compared.
Results: 1-year survival rates and 50% survival period for each group were as follows: Group A: 33%, 5.9 months; Group B: 22%. 4.8 months; and Group C: 6%, 3.9 months, respectively. One case from Group A2a and 2 cases from Group B2a have survived for 3 years or longer.
Conclusion: 1) We treated 3 patients with liver metastasis from gastric cancer who survived for 3 years or longer. 2) Resection of the primary lesion along with hepatic intraarterial infusion therapy (in addition to hepatic resection), especially in combination with FEM therapy, provided an extended length of survival.

3Z8479ZZ5X (Epirubicin)
50SG953SK6 (Mitomycin)
U3P01618RT (Fluorouracil)

FEM protocol

Date Created: 20031119 Date Completed: 20031125 Latest Revision: 20131121

20221213

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