Expression of heme oxygenase-1 and regulation by cytokines in human osteoarthritic chondrocytes.

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  • Additional Information
    • Source:
      Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print Cited Medium: Print ISSN: 0006-2952 (Print) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE
    • Publication Information:
      Publication: Oxford : Elsevier Science
      Original Publication: Oxford, New York [etc.] Paragamon Press.
    • Subject Terms:
      Gene Expression Regulation, Enzymologic*; Chondrocytes/*drug effects ; Cytokines/*pharmacology ; Heme Oxygenase (Decyclizing)/*genetics ; Osteoarthritis/*pathology; Aged ; Chondrocytes/enzymology ; Female ; Heme Oxygenase-1 ; Humans ; Interleukin-1/pharmacology ; Interleukin-10/pharmacology ; Interleukin-17/pharmacology ; Male ; Membrane Proteins
    • Abstract:
      Heme oxygenase-1 (HO-1) is implicated in the protection against tissue injury. We investigated the expression of this protein in cartilage sections and chondrocytes obtained from osteoarthritic patients. HO-1 was immunodetected in preparations from cartilage and also in chondrocytes cultured in the absence of stimulation. We found that HO-1 can be modulated by cytokines since the pro-inflammatory cytokines interleukin (IL)-1beta, IL-17 and tumour necrosis factor-alpha (TNF-alpha) down-regulated this protein, whereas the anti-inflammatory cytokine IL-10 exerted the opposite effect. Our results suggest a role for HO-1 as part of protective mechanisms against tissue injury in human cartilage.
    • Accession Number:
      0 (Cytokines)
      0 (Interleukin-1)
      0 (Interleukin-17)
      0 (Membrane Proteins)
      130068-27-8 (Interleukin-10)
      EC 1.14.14.18 (HMOX1 protein, human)
      EC 1.14.14.18 (Heme Oxygenase (Decyclizing))
      EC 1.14.14.18 (Heme Oxygenase-1)
    • Publication Date:
      Date Created: 20031106 Date Completed: 20031219 Latest Revision: 20190623
    • Publication Date:
      20231215
    • Accession Number:
      10.1016/s0006-2952(03)00543-4
    • Accession Number:
      14599563