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Intraperitoneal chemotherapy with mitoxantrone in malignant ascites.
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- Additional Information
- Source:
Publisher: Saunders Country of Publication: United States NLM ID: 9211789 Publication Model: Print Cited Medium: Print ISSN: 1055-3207 (Print) Linking ISSN: 10553207 NLM ISO Abbreviation: Surg Oncol Clin N Am Subsets: MEDLINE
- Publication Information:
Original Publication: Philadelphia : Saunders, c1992-
- Subject Terms:
- Abstract:
A retrospective analysis of intraperitoneal mitoxantrone instillation therapy for malignant ascites in advanced breast and gynecologic pelvic cancers was performed to confirm the efficacy and safety of this therapy. Several smaller phase II trials had suggested good palliative effects. In 143 patients (37 breast cancer and 106 gynecologic cancers), 257 instillations were registered. Response in breast cancer was induced in 49% and in 63% with gynecologic cancer. Severe or life-threatening clinical or laboratory side effects related to intraperitoneal mitoxantrone occurred in 2.7% (clinical) or 1.9% (laboratory) of the 257 instillations. Induction of adverse side effect was dose dependent. Intraperitoneal chemotherapy with mitoxantrone for treatment of malignant ascites in breast cancer and gynecologic malignancy is effective and well tolerated. For this treatment 30 mg mitoxantrone in > or = 1000 mL carrier solution (e.g., saline) is recommended. A minimal concentration of at least 10 micrograms/mL should be achieved.
- Number of References:
25
- Accession Number:
BZ114NVM5P (Mitoxantrone)
- Publication Date:
Date Created: 20031022 Date Completed: 20031120 Latest Revision: 20191108
- Publication Date:
20221213
- Accession Number:
10.1016/s1055-3207(03)00050-4
- Accession Number:
14567037
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