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Sequence of Escherichia coli O128 antigen biosynthesis cluster and functional identification of an alpha-1,2-fucosyltransferase.
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- Author(s): Shao J;Shao J; Li M; Jia Q; Lu Y; Wang PG
- Source:
FEBS letters [FEBS Lett] 2003 Oct 09; Vol. 553 (1-2), pp. 99-103.
- Publication Type:
Journal Article
- Language:
English
- Additional Information
- Source:
Publisher: John Wiley & Sons Ltd Country of Publication: England NLM ID: 0155157 Publication Model: Print Cited Medium: Print ISSN: 0014-5793 (Print) Linking ISSN: 00145793 NLM ISO Abbreviation: FEBS Lett Subsets: MEDLINE
- Publication Information:
Publication: Jan. 2016- : West Sussex : John Wiley & Sons Ltd.
Original Publication: Amsterdam, North-Holland on behalf of the Federation of European Biochemical Societies.
- Subject Terms:
- Abstract:
O128 is one of the most common atypical enteropathogenic Escherichia coli isolated from diarrhea patients worldwide. The primary structure of E. coli O128 repeat units has previously been determined as -->3)-beta-D-GalNAc-(1-->4)-alpha-D-Gal-(1-->3)-beta-D-GalNAc-(1-->6)-[alpha-L-Fuc-(1-->2)]-beta-D-Gal-(1--> pentasaccharide. Here we report the complete sequencing of E. coli O128 antigen biosynthesis gene cluster and its flanking regions. Comparative sequence analysis revealed the expected O128 antigen process genes, GDP-fucose biosynthesis genes and four potential glycosyltransferase genes responsible for the assembly of E. coli O128 antigen repeats. WbsJ was shown to encode an alpha-1,2-fucosyltransferase by enzymatic assays and nuclear magnetic resonance spectroscopy analysis.
- Molecular Sequence:
GENBANK AY217096
- Accession Number:
0 (Antigens, Bacterial)
0 (Escherichia coli Proteins)
EC 2.4.1.- (Fucosyltransferases)
- Publication Date:
Date Created: 20031011 Date Completed: 20031112 Latest Revision: 20231213
- Publication Date:
20231215
- Accession Number:
10.1016/s0014-5793(03)00980-3
- Accession Number:
14550554
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