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儿童核心结合因子相关急性髓系白血病临床特征及预后分析. (Chinese)
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- Author(s): 刘超; 陈晓燕; 易美慧; 吴文齐; 阮敏; 竺晓凡
- Source:
Chinese Journal of Contemporary Pediatrics; 2020, Vol. 22 Issue 7, p739-743, 5p- Subject Terms:
- Source:
- Additional Information
- Alternate Title: Clinical features and prognosis of core binding factor acute myeloid leukemia in children. (English)
- Abstract: Objective To study the clinical features and prognosis of core binding factor acute myeloid leukemia (CBF-AML) in children. Methods A retrospective analysis was performed from the chart review data of children who were newly diagnosed with CBF-AML in the Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences, from August 2009 to November 2015. According to the type of fusion gene, the children were divided into CBFB-MYH11 and AML1-ETO groups. Clinical features and prognosis were analyzed and compared between the two groups. Results A total of 91 children with CBF-AML were enrolled in this study, among whom there were 74 (81%) in the AML1-ETO group and 17 (19%) in the CBFB-MYH11 group. Additional chromosomal abnormalities were observed in 38 children (42%), and deletion of sex chromosome was the most common abnormality and was observed in 28 children (31%). After the first course of induction treatment, the complete remission rate was 97% (88/91), the recurrence rate was 29% (26/91), the 5-year event-free survival (EFS) rate was 65%±6%, and the 5-year overall survival (OS) rate was 75%±5%. There were no significant differences between the AML1-ETO and CBFB-MYH11 groups in 5-year EFS rate (62%±7% vs 77%±11%, P > 0.05) or 5-year OS rate (72%±6% vs 88%±9%, P > 0.05). Conclusions AML1-ETO is the main type of fusion gene in children with CBF-AML, and deletion of sex chromosome is the most common type of additional chromosomal abnormalities. Children with CBF-AML often have a good prognosis, and the children with AML1-ETO have a similar prognosis to those with CBFB-MYH11. [ABSTRACT FROM AUTHOR]
- Abstract: 目的 分析儿童核心结合因子相关急性髓系白血病(CBF-AML)的临床特征及疗效。方法 回顾性分析2009年8月至2015年11月于中国医学科学院血液病医院确诊的初诊CBF-AML患儿的临床资料,根据融合基因类型,分为CBFB-MYH11组和AML1-ETO组。总结并比较其临床特征及预后。结果 共纳入91例初诊CBF-AML患儿,其中AML1-ETO组74例(81%),CBFB-MYH11组17例(19%)。38例(42%)患儿伴有附加染色体异常,其中性染色体缺失28例(31%)最为常见。第1个疗程诱导治疗完全缓解率为97%(88/91),复发率为29%(26/91),5年EFS率为65%±6%,5年OS率为75%±5%。AML1-ETO、CBFB-MYH11组5年EFS率分别为62%±7%、77%±11%(P > 0.05)。AML1-ETO、CBFB-MYH11组5年OS率分别为72%±6%、88%±9%(P > 0.05)。结论 儿童CBF-AML以AML1-ETO为主,性染色体缺失为最常见的附加染色体异常,预后较好,AML1-ETO与CBFB-MYH11患儿预后相当。 [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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