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Regioselective synthesis and anticancer evaluation of H2O2-activable nucleosides.
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- Author(s): Sun, Ying-Jie1,2 (AUTHOR); Liu, Li1,2 (AUTHOR); Cheng, Liang1,2 (AUTHOR)
- Source:
Chemical Communications. 6/18/2020, Vol. 56 Issue 48, p6484-6487. 4p.
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- Additional Information
- Abstract:
We describe here the design, synthesis, and biological evaluation of H2O2-activatable nucleosides via an efficient and regioselective functionalization of unprotected precursors. Biological evaluation of a H2O2-specific responsive prodrug of gemecitabin demonstrates an extremely fast activation, low toxicity and enhanced anticancer effects in two cell lines. [ABSTRACT FROM AUTHOR]
- Abstract:
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