[Heparan sulfate: its kinetic effects on fibrinolytic-coagulative parameters after oral administration].

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  • Author(s): Agrati AM;Agrati AM; De Bartolo G; Palmieri G
  • Source:
    Minerva medica [Minerva Med] 1992 Sep; Vol. 83 (9), pp. 533-6.
  • Publication Type:
    Clinical Trial; English Abstract; Journal Article; Randomized Controlled Trial
  • Language:
    Italian
  • Additional Information
    • Transliterated Title:
      Eparansolfato: cinetica degli effetti su parametri fibrinolitico-coagulativi dopo somministrazione orale.
    • Source:
      Publisher: Edizioni Minerva Medica Country of Publication: Italy NLM ID: 0400732 Publication Model: Print Cited Medium: Print ISSN: 0026-4806 (Print) Linking ISSN: 00264806 NLM ISO Abbreviation: Minerva Med Subsets: MEDLINE
    • Publication Information:
      Original Publication: Torino : Edizioni Minerva Medica
    • Subject Terms:
      Blood Coagulation/*drug effects ; Fibrinolysis/*drug effects ; Heparitin Sulfate/*pharmacokinetics; Administration, Oral ; Adult ; Dose-Response Relationship, Drug ; Heparitin Sulfate/administration & dosage ; Heparitin Sulfate/pharmacology ; Humans ; Male ; Reference Values ; Research Design ; Time Factors
    • Abstract:
      The effects of the oral administration of 100 or 200 mg of heparan sulphate or placebo over time were assessed in nine healthy volunteers. Blood samples were collected at 1, 2, 4, 6, 8 and 12 hours after administration to assay prothrombin activity, partially activated thromboplastin time, and the activation to tPA and PAI-1. A significant increase (P < 0.001) of tPA activity and a reduced inhibition of fibrinolytic systems by PAI-1 were observed. These effects, which were clearly dose-dependent, appeared 2 hours after administration and persisted for 6-8 hours. On the contrary, no changes were recorded in coagulative tests at the doses used.
    • Accession Number:
      9050-30-0 (Heparitin Sulfate)
    • Publication Date:
      Date Created: 19920901 Date Completed: 19921217 Latest Revision: 20061115
    • Publication Date:
      20231215
    • Accession Number:
      1436603