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Killer cells add fire to fuel immunotherapy.
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- Abstract:
The article focuses on cytotoxic lymphocytes including natural killer (NK) cells and cytotoxic T lymphocytes mediate antiviral and antitumoral immunity. It mentions Perforin delivers granzyme B (GZMB) into target cells, where it initiates apoptosis, a noninflammatory form of programmed cell death. It also mentions discovery of a new mechanism of cytotoxicity in which granzyme A (GZMA), delivered to certain target cells by NK cells and CTLs and response to immune checkpoint therapy.
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