Naše izkušnje z zdravilom bevacizumab v primarnem zdravljenju epitelijskega raka jajčnikov. (Slovenian)

Our experience with bevacizumab in the primary treatment of epithelial ovarian cancer. (English)

Introduction: Bevacizumab has been used in advanced epithelial ovarian cancer patients as a part of standard primary systemic therapy together with paclitaxel and carboplatin combination chemotherapy since 2013. Aim of study: To evaluate the safety and efficacy of bevacizumab in treatment of patients with advanced epithelial ovarian cancer in daily clinical practice. Methods: Retrospective analysis of patients with advanced epithelial cancer treated with bevacizumab at the Institute of Oncology Ljubljana in the period from 1 Jan 2013 to 31 Dec 2016. The end points of the study were safety and efficacy (relapse-free survival, overall survival). The study was approved by our institutional ethics board. Results: In the observed period, a total of 111 patients with advanced epithelial ovarian cancer were treated with bevacizumab. The most common adverse events were: pain (52%), bleeding (45%), and arterial hypertension (44%). Serious adverse events (grade 3/4) were observed in 12% of patients: 3% venous thrombosis/ embolism, 3% proteinuria, 2% arterial hypertension, 2% bleeding, 1% pain, and 1% fistula. Median follow up was 59 months. Median progression-free survival was 18 months, while median overall survival was 41 months. Conclusions: Treatment with bevacizumab in daily clinical practice is safe and effective - in concordance with published data from prospective studies GOG 218 and ICON 7. [ABSTRACT FROM AUTHOR]

Izhodišče: Zdravilo bevacizumab uporabljamo v sklopu primarnega sistemskega zdravljenja napredovalega epitelijskega raka jajčnikov v kombinaciji s paklitakselom in karboplatinom od leta 2013. Namen: Prikazati učinkovitost in varnost zdravljenja z bevacizumabom v redni klinični praksi v sklopu primarnega zdravljenja raka jajčnikov. Metode: V retrospektivno analizo smo vključili bolnice z epitelijskim rakom jajčnikov, ki so se zdravile z bevacizumabom na Onkološkem inštitutu Ljubljana v obdobju od 1. 1. 2013 do 31. 12. 2016. Cilja raziskave sta bila varnost in učinkovitost (preživetje brez ponovitve bolezni, celokupno preživetje) zdravljenja z bevacizumabom. Raziskavo je odobrila etična komisija na Onkološkem inštitutu Ljubljana. Rezultati: V opazovanem obdobju je bilo z bevacizumabom zdravljenih 111 bolnic z napredovalim epitelijskim rakom jajčnikov. Najpogostejši neželeni učinki so bili: bolečine (52 %), krvavitev (45 %), arterijska hipertenzija (44 %). Resne neželene učinke (stopnja 3/4) je imelo 12 % bolnic: venska tromboza/ embolija (3 %), proteinurija (3 %), arterijska hipertenzija (2 %), krvavitev (2 %), bolečine (1 %), fistula (1 %). Mediani čas sledenja je bil 59 mesecev. Mediano preživetje brez ponovitve bolezni je bilo 18 mesecev, mediano celokupno preživetje pa 41 mesecev. Zaključki: Zdravljenje z bevacizumabom v redni klinični praksi je varno in učinkovito - v skladu z do zdaj znanimi rezultati prospektivnih raziskav GOG 218 in ICON 7. [ABSTRACT FROM AUTHOR]

Copyright of Onkologija is the property of Institute of Oncology Ljubljana and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)