STABILITY OF THE MYELIN MEMBRANE.

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  • Author(s): O'BRIEN JS
  • Source:
    Science (New York, N.Y.) [Science] 1965 Mar 05; Vol. 147 (3662), pp. 1099-107.
  • Publication Type:
    Journal Article; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Print ISSN: 0036-8075 (Print) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: OLDMEDLINE
    • Publication Information:
      Publication: : Washington, DC : American Association for the Advancement of Science
      Original Publication: New York, N.Y. : [s.n.] 1880-
    • Subject Terms:
      Cerebrosides* ; Chemical Phenomena* ; Chemistry* ; Cholesterol* ; Electrons* ; Lipids* ; Microscopy* ; Microscopy, Electron* ; Myelin Sheath* ; Neurochemistry* ; Peripheral Nerves* ; Phospholipids* ; Sphingolipids* ; Sphingomyelins*; Humans
    • Abstract:
      The hypothetical questions which were asked earlier may now be answered as follows. Myelin lipids do possess characteristics which could lead to a tightly organized, closely packed, highly stable membrane structure, while lipids in adjacent neurons and glial cells do possess characteristics which could give rise to a more loosely organized, less stable membrane structure. The greater degree of metabolic inertness of myelin lipids may be explained on this basis. The stability of myelin itself may also be based largely on the intermolecular cohesion between lipid molecules, since the lipid content of myelin is extraordinarily high. Physiological and clinical studies tend to support the concept that a surfeit of polyunsaturated lipids or a deficiency of long-chain sphingolipids can result in a more easily disrupted membrane. The most important prediction to be drawn from these speculations is that myelin may be rendered unstable in disease if its lipid composition is altered so that higher proportions of lipids containing polyunsaturated fatty acids and lower proportions of lipids containing very-long-chain fatty acids are present.
    • Number of References:
      0
    • Contributed Indexing:
      Keywords: CHEMISTRY*; CHOLESTEROL*; LIPIDS*; MICROSCOPY, ELECTRON*; MYELIN SHEATH*; NEUROCHEMISTRY*; PERIPHERAL NERVES*; PHOSPHOLIPIDS*; REVIEW*; SPHINGOMYELINS*
    • Accession Number:
      0 (Cerebrosides)
      0 (Lipids)
      0 (Phospholipids)
      0 (Sphingolipids)
      0 (Sphingomyelins)
      97C5T2UQ7J (Cholesterol)
    • Publication Date:
      Date Created: 19650305 Date Completed: 19961201 Latest Revision: 20190619
    • Publication Date:
      20231215
    • Accession Number:
      10.1126/science.147.3662.1099
    • Accession Number:
      14242030