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John L. Dart Library
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Phone: (843) 722-7550
West Ashley Library
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Folly Beach Library
9 a.m. - 2 p.m.
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Edgar Allan Poe/Sullivan's Island Library
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Wando Mount Pleasant Library
9 a.m. - 5 p.m.
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Village Library
9 a.m. - 1 p.m.
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9 a.m. - 5 p.m.
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Mapping WOMAC Onto the EQ-5D-5L Utility Index in Patients With Hip or Knee Osteoarthritis.
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- Author(s): Bilbao, Amaia1,2,3 (AUTHOR) ; Martín-Fernández, Jesús2,4,5 (AUTHOR); García-Pérez, Lidia2,6 (AUTHOR); Arenaza, Juan Carlos2,7 (AUTHOR); Ariza-Cardiel, Gloria2,4 (AUTHOR); Ramallo-Fariña, Yolanda2,6 (AUTHOR); Ansola, Laura1 (AUTHOR)
- Source:
Value in Health. Mar2020, Vol. 23 Issue 3, p379-387. 9p.- Subject Terms:
*STANDARD deviations; *OSTEOARTHRITIS; *INTRACLASS correlation; *KNEE; *AKAIKE information criterion; *QUALITY of life; *HIP joint diseases diagnosis; *OSTEOARTHRITIS diagnosis; *KNEE diseases; *HIP joint diseases; *RESEARCH; *PAIN measurement; *PREDICTIVE tests; *TIME; *HIP joint; *RESEARCH methodology; *DISABILITY evaluation; *JOINT pain; *EVALUATION research; *MEDICAL cooperation; *COMPARATIVE studies; *QUESTIONNAIRES; *QUALITY-adjusted life years; *LONGITUDINAL method; RESEARCH evaluation - Source:
- Additional Information
- Abstract:
Objectives: To map the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) onto the EQ-5D-5L in patients with hip or knee osteoarthritis (OA).Methods: A prospective observational study was conducted on 758 patients with hip or knee OA who completed the EQ-5D-5L and WOMAC questionnaires, of whom 644 completed them both again 6 months later. Baseline data were used to derive mapping functions. Generalized additive models were used to identify to which powers the WOMAC subscales should be raised to achieve a linear relationship with the response. For the modeling, general linear models (GLM), Tobit models, and beta regression models were used. Age, sex, and affected joints were also considered. Preferred models were selected based on Akaike and Bayesian information criteria, adjusted R2, mean absolute error (MAE), and root mean squared error (RMSE). The functions were validated with the follow-up data using MAE, RMSE, and the intraclass correlation coefficient.Results: The preferred models were a GLM with Pain2+Pain3+Function+Pain·Function as covariates and a beta model with Pain3+Function+Function2+Function3 as covariates. The adjusted R2 were similar (0.6190 and 0.6136, respectively). The predictive performance of these models in the validation sample was similar and both models showed an overprediction for health states worse than death.Conclusion: To our knowledge, these are the first functions mapping the WOMAC onto the EQ-5D-5L in patients with hip or knee OA. They showed an acceptable fit and precision and could be very useful for clinicians and researchers when cost-effectiveness studies are needed and generic preference-based health-related quality of life instruments to derive utilities are not available. [ABSTRACT FROM AUTHOR] - Abstract: Copyright of Value in Health is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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