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In vitro activity of a novel antibacterial agent, levonadifloxacin, against clinical isolates collected in a prospective, multicentre surveillance study in India during 2016-18.
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- Author(s): Appalaraju, Boppe; Baveja, Sujata; Baliga, Shrikala; Shenoy, Suchitra; Bhardwaj, Renu; Kongre, Vaishali; Dattatraya, Gogi Suresh; Dhole, Tapan; Verma, Binita; Mukherjee, D N; Gupta, Shalini; Shanmugam, Priyadarshini; Iravane, Jyoti; Mishra, Sudhi Ranjan; Barman, Purabi; Chopra, Shimpi; Hariharan, Meenakshi; Surpam, Rajendra; Pratap, Rana; Joshi, Prashant
- Source:
Journal of Antimicrobial Chemotherapy (JAC); Mar2020, Vol. 75 Issue 3, p600-608, 9p- Subject Terms:
ANTIBACTERIAL agents; ACINETOBACTER baumannii; STREPTOCOCCUS pneumoniae; STAPHYLOCOCCUS aureus; ANTIBIOTICS; STAPHYLOCOCCUS; DIABETIC foot; RESEARCH; HETEROCYCLIC compounds; RESEARCH methodology; METHICILLIN-resistant staphylococcus aureus; MEDICAL cooperation; EVALUATION research; COMPARATIVE studies; QUINOLONE antibacterial agents; LONGITUDINAL method; MICROBIAL sensitivity tests; PHARMACODYNAMICS - Source:
- Additional Information
- Subject Terms:
- Abstract:
Background: Levonadifloxacin is a novel antibiotic belonging to the benzoquinolizine subclass of fluoroquinolones with potent activity against MRSA and quinolone-resistant Staphylococcus aureus. IV levonadifloxacin and its oral prodrug alalevonadifloxacin have recently been approved in India for the treatment of acute bacterial skin and skin structure infections (ABSSSIs) including diabetic foot infections.Objectives: To investigate the in vitro activity of levonadifloxacin against contemporary clinical isolates collected from multiple tertiary care hospitals across India in the Antimicrobial Susceptibility Profiling of Indian Resistotypes (ASPIRE) surveillance study.Methods: A total of 1376 clinical isolates, consisting of staphylococci (n = 677), streptococci (n = 178), Enterobacterales (n = 320), Pseudomonas aeruginosa (n = 140) and Acinetobacter baumannii (n = 61), collected (2016-18) from 16 tertiary hospitals located across 12 states in India, were included in the study. The MICs of levonadifloxacin and comparator antibiotics were determined using the reference agar dilution method and broth microdilution method.Results: Levonadifloxacin exhibited potent activity against MSSA (MIC50/90: 0.5/1 mg/L), MRSA (MIC50/90: 0.5/1 mg/L) and levofloxacin-resistant S. aureus (MIC50/90: 1/1 mg/L) isolates. Similarly, potent activity of levonadifloxacin was also observed against CoNS including MDR isolates (MIC50/90: 1/2 mg/L). Against Streptococcus pneumoniae, levonadifloxacin (MIC50/90: 0.5/0.5 mg/L) showed superior activity compared with levofloxacin (MIC50/90: 1/2 mg/L). Among levofloxacin-susceptible Enterobacterales, 80.6% of isolates were inhibited at ≤2 mg/L levonadifloxacin.Conclusions: Levonadifloxacin displayed potent activity against contemporary MRSA and fluoroquinolone-resistant staphylococcal isolates, thus offering a valuable IV as well as an oral therapeutic option for the treatment of ABSSSIs. Furthermore, levonadifloxacin exhibited a broad-spectrum activity profile as evident from its activity against streptococci and levofloxacin-susceptible Gram-negative isolates. [ABSTRACT FROM AUTHOR] - Abstract: Copyright of Journal of Antimicrobial Chemotherapy (JAC) is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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