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Wando Mount Pleasant Library
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Evaluation of the diagnostic value of peripheral BDNF levels for Alzheimer's disease and mild cognitive impairment: results of a meta-analysis.
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- Author(s): Xie, Bing (AUTHOR); Zhou, Huimin (AUTHOR); Liu, Wenxuan (AUTHOR); Yu, Weifang (AUTHOR); Liu, Zanchao (AUTHOR); Jiang, Lei (AUTHOR); Zhang, Rui (AUTHOR); Cui, Dongsheng (AUTHOR); Shi, Zhongli (AUTHOR); Xu, Shunjiang (AUTHOR)
- Source:
International Journal of Neuroscience. Mar2020, Vol. 130 Issue 3, p218-230. 13p. - Source:
- Additional Information
- Subject Terms:
- Abstract: Deregulation of brain-derived neurotrophic factor (BDNF) is a possible contributor to the pathology and symptoms of Alzheimer's disease (AD). Most studies support an association between the dysfunction of BDNF and the pathogenesis of AD. This study aimed to evaluate the diagnostic value of peripheral BDNF levels in patients with AD and mild cognitive impairment (MCI) using meta-analytic techniques. A systematic search of the MEDLINE, EMBASE, ISI Web of Science, and the Cochrane Central database was performed and 34 eligible articles were identified for inclusion in the meta-analysis. Random-effects meta-analysis showed that AD patients had significantly decreased levels of peripheral BDNF compared with healthy control (HC) subjects (Hedges' g = − 0.725, 95% CI = −1.06 to − 0.39, p < 0.01). MCI patients showed a same trend with decreased BDNF levels compared with HC subjects (Hedges' g = − 0.296, 95% CI = − 0.57 to − 0.02, p < 0.01). Significant differences were found between AD and MCI subjects in peripheral BDNF levels (Hedges' g = − 0.462, 95% CI = − 0.95 to 0.03, p < 0.01). However, the ROC curve analysis revealed that the peripheral BDNF levels may not be an optimal biomarker potentially for AD and MCI diagnosis with a lower AUC (AD: 0.707; MCI: 0.573), less sensitivity (AD: 66.67%; MCI: 50.00%) and poor specificity (AD: 93.33%; MCI: 83.33%). These results suggested that AD or MCI is accompanied by reduction of peripheral BDNF, but the levels of circulating BDNF may not be suitable as a diagnostic marker for AD and MCI. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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