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Folly Beach Library
9 a.m. - 5:30 p.m.
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
West Ashley Library
9 a.m. - 7 p.m.
Phone: (843) 766-6635
Wando Mount Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. - 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 849-6161
McClellanville Library
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Keith Summey North Charleston Library
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John's Island Library
9 a.m. - 8 p.m.
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Hurd/St. Andrews Library
9 a.m. - 8 p.m.
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Miss Jane's Building (Edisto Library Temporary Location)
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Dorchester Road Library
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Phone: (843) 722-7550
Baxter-Patrick James Island
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Phone: (843) 795-6679
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Phone: (843) 805-6930
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Clinical features and treatment outcomes of limited-stage mantle cell lymphoma: Consortium for Improving Survival of Lymphoma report.
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- Author(s): Jo, Jae-Cheol; Kim, Seok Jin; Lee, Ho Sup; Eom, Hyeon-Seok; Lee, Soon Il; Park, Yong; Lee, Jeong-Ok; Lee, Yoojin; Yhim, Ho-Young; Yang, Deok-Hwan; Byun, Ja Min; Kang, Hye Jin; Kim, Hyo Jung; Shin, Ho-Jin; Yoo, Kwai Han; Suh, Cheolwon; and Consortium for Improving Survival of Lymphoma (CISL)
- Source:
Annals of Hematology; Feb2020, Vol. 99 Issue 2, p223-228, 6p- Subject Terms:
MANTLE cell lymphoma; TREATMENT effectiveness; SURGICAL excision; LACTATE dehydrogenase; LYMPHOMAS; LYMPHOMA treatment; LYMPHOMA diagnosis; RESEARCH; DOXORUBICIN; TIME; RESEARCH methodology; ANTINEOPLASTIC agents; PROGNOSIS; RETROSPECTIVE studies; EVALUATION research; MEDICAL cooperation; TUMOR classification; COMPARATIVE studies; CYCLOPHOSPHAMIDE; RADIOTHERAPY; PREDNISONE; VINCRISTINE; LONGITUDINAL method - Source:
- Additional Information
- Abstract: Limited-stage (Ann Arbor stage I or II) mantle cell lymphoma (MCL) is an extremely rare disease. Thus, there is little data on the clinical features and treatment outcomes of patients with early-stage MCL. We examined consecutive stage I or II MCL 41 cases diagnosed between 2000 and 2016 in 16 institutions of the Consortium for Improving Survival of Lymphoma group. All cases were pathologically confirmed and systemic evaluation was performed for staging. The clinical features were reviewed, and the treatment outcomes were analyzed. The median age of patients was 66 years (range 19-85 years); there were more men (n = 31, 75.6%) than women. Most patients (n = 28, 68.3%) had stage 2 disease, and 29 (70.7%) were symptomatic. The elevation of lactate dehydrogenase (n = 2, 4.9%) was not common; thus, 39 patients (95.1%) had a low-risk score (0 or 1) for the International Prognostic Index, and 28 (68.3%) had a low-risk score (1-3) for the MCL International Prognostic Index. Most patients (n = 37, 90.1%) received chemotherapy as the first therapeutic strategy, while some received radiotherapy (n = 2), surgical resection (n = 1), or no treatment (n = 1). Of the patients who received chemotherapy, 23 (56.9%) received a rituximab-containing regimen, and R-CHOP (n = 17) and R-bendamustine (n = 5) were commonly used. The best response was noted in 97.4% (n = 38) of patients, including 32 who showed a complete response (78%). With a median follow-up duration of 40.6 months, the 42 months relapse-free survival was 59.1%, and the 5-year overall survival rate was 80.4%. Limited-state MCL showed indolent clinical and low-risk prognostic features. Chemotherapy could be effective for controlling localized MCL lesions, with high complete response rates. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Annals of Hematology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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