[Prevention of liver metastasis by intrasplenic injection of OK-432].

Publisher: Gan To Kagaku Ryohosha Country of Publication: Japan NLM ID: 7810034 Publication Model: Print Cited Medium: Print ISSN: 0385-0684 (Print) Linking ISSN: 03850684 NLM ISO Abbreviation: Gan To Kagaku Ryoho Subsets: MEDLINE

Publication: Tokyo : Gan To Kagaku Ryohosha
Original Publication: Tōkyō, Gan to Kagaku Ryōhōsha [1974?]-

Adenocarcinoma/*secondary ; Colonic Neoplasms/*pathology ; Liver Neoplasms/*prevention & control ; Liver Neoplasms/*secondary ; Picibanil/*therapeutic use; Adenocarcinoma/immunology ; Animals ; Colonic Neoplasms/immunology ; Injections ; Leukocyte Count ; Lymphocyte Subsets ; Male ; Mice ; Mice, Inbred C57BL ; Receptors, Interleukin-2/analysis ; Spleen ; T-Lymphocytes, Regulatory

The effects of OK-432 on artificial liver metastasis of tumor-bearing mice were assessed using murine colon adenocarcinoma MCA-38 in C57 BL/6 mice. OK-432 injection into the spleen reduced the liver metastases. In gastro-intestinal cancer patients, the effects of OK-432 injection into the spleen were assessed with functional T cell subsets. The treatment resulted in an increase in the number of cytotoxic T cells, but a decrease in the suppressor T cells. The facts suggested that OK-432 injection into the spleen had an ability to prevent liver metastases.

0 (Receptors, Interleukin-2)
39325-01-4 (Picibanil)

Date Created: 19920801 Date Completed: 19921020 Latest Revision: 20061115

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