The effect of morphine on the adrenergic nerves of the isolated guinea-pig jejunum.

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  • Author(s): SZERB JC
  • Source:
    British journal of pharmacology and chemotherapy [Br J Pharmacol Chemother] 1961 Feb; Vol. 16, pp. 23-31.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: British Medical Assn Country of Publication: England NLM ID: 0154627 Publication Model: Print Cited Medium: Print ISSN: 0366-0826 (Print) Linking ISSN: 03660826 NLM ISO Abbreviation: Br J Pharmacol Chemother Subsets: OLDMEDLINE
    • Publication Information:
      Original Publication: London, British Medical Assn.
    • Subject Terms:
      Adrenergic Agents* ; Atropine* ; Histamine* ; Jejunum* ; Muscles* ; Norepinephrine*; Intestines/*pharmacology ; Morphine/*pharmacology; Guinea Pigs
    • Abstract:
      Nerves accompanying the mesenteric blood-vessels of the isolated guinea-pig jejunum were stimulated and changes in the longitudinal muscle coat were recorded. Stimulation of the nerves led to a rapid relaxation if the intestine was contracted by a previous administration of histamine. The relaxation was inhibited by morphine and partially restored by nalorphine. Bretylium and atropine also inhibited the relaxation and cocaine increased it somewhat. Morphine, atropine, and bretylium had no significant effect on the depressant action of noradrenaline on histamine contractions, whereas cocaine slightly enhanced the action of noradrenaline. Morphine, but not the other drugs, prevented the inhibitory action of dopamine.
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    • Contributed Indexing:
      Keywords: INTESTINES/pharmacology*; MORPHINE/pharmacology*
    • Accession Number:
      0 (Adrenergic Agents)
      76I7G6D29C (Morphine)
      7C0697DR9I (Atropine)
      820484N8I3 (Histamine)
      X4W3ENH1CV (Norepinephrine)
    • Publication Date:
      Date Created: 19610201 Date Completed: 19981101 Latest Revision: 20190513
    • Publication Date:
      20221213
    • Accession Number:
      PMC1482004
    • Accession Number:
      10.1111/j.1476-5381.1961.tb00294.x
    • Accession Number:
      13774578