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Folly Beach Library
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Wando Mount Pleasant Library
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From a Philosophical Framework to a Valid Prognostic Staging System of the New "Comprehensive Assessment" for Transplantable Hepatocellular Carcinoma.
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- Author(s): Di Sandro, Stefano; Bagnardi, Vincenzo; Cucchetti, Alessandro; Lauterio, Andrea; De Carlis, Riccardo; Benuzzi, Laura; Danieli, Maria; Botta, Francesca; Centonze, Leonardo; Najjar, Marc; De Carlis, Luciano
- Source:
Cancers; Jun2019, Vol. 11 Issue 6, p741, 1p- Subject Terms:
- Source:
- Additional Information
- Subject Terms:
- Abstract: The comprehensive assessment of the transplantable tumor (TT) proposed and included in the last Italian consensus meeting still deserve validation. All consecutive patients with hepatocellular carcinoma (HCC) listed for liver transplant (LT) between January 2005 and December 2015 were post-hoc classified by the tumor/patient stage as assessed at the last re-staging-time (ReS-time) before LT as follow: high-risk-class (HRC) = stages TT
DR , TTPR ; intermediate-risk-class (IRC) = TT0NT , TTFR , TTUT ; low-risk-class (LRC) = TT1, TT0L , TT0C . Of 376 candidates, 330 received LT and 46 dropped-out. Transplanted patients were: HRC for 159 (48.2%); IRC for 63 (19.0%); LRC for 108 (32.7%). Cumulative incidence function (CIF) of tumor recurrence after LT was 21%, 12%, and 8% at 5-years and 27%, 15%, and 12% at 10-years respectively for HRC, IRC, and LRC (P = 0.011). IRC patients had significantly lower CIF of recurrence after LT if transplanted >2-months from ReS-time (28% vs. 3% for <2 and >2 months, P = 0.031). HRC patients had significantly lower CIF of recurrence after-LT if transplanted <2 months from the ReS-time (10% vs. 33% for <2 and >2 months, P = 0.006). The proposed TT staging system can adequately describe the post-LT recurrence, especially in the LRC and HRC patients. The intermediate-risk-class needs to be better defined and further studies on its ability in defining intention-to-treat survival (ITT) and drop-out are required. [ABSTRACT FROM AUTHOR] - Abstract: Copyright of Cancers is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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