Antihistaminase activity of serpentine.

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  • Author(s): SACHDEV KS; AIMAN R; RAJAPURKAR MV
  • Source:
    British journal of pharmacology and chemotherapy [Br J Pharmacol Chemother] 1961 Apr; Vol. 16, pp. 146-52.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: British Medical Assn Country of Publication: England NLM ID: 0154627 Publication Model: Print Cited Medium: Print ISSN: 0366-0826 (Print) Linking ISSN: 03660826 NLM ISO Abbreviation: Br J Pharmacol Chemother Subsets: OLDMEDLINE
    • Publication Information:
      Original Publication: London, British Medical Assn.
    • Subject Terms:
      Alkaloids* ; Guanidines* ; Histamine* ; Ileum* ; Trachea*; Amine Oxidase (Copper-Containing)/*antagonists & inhibitors ; Rauwolfia/*pharmacology; Guinea Pigs
    • Abstract:
      Serpentine, an alkaloid of Rauwolfia serpentina, specifically potentiates histamine responses of guinea-pig ileum, uterus, and tracheal chain. It also inhibits histaminase in vitro. Its antihistaminase activity is equivalent to that of aminoguanidine.
    • References:
      Nature. 1955 Oct 8;176(4484):701. (PMID: 13265813)
      Lancet. 1959 May 23;1(7082):1064-9. (PMID: 13655671)
      J Pharmacol Exp Ther. 1957 Oct;121(2):191-8. (PMID: 13481842)
      Acta Physiol Scand. 1954 Nov;32(2-3):230-7. (PMID: 13228111)
      J Physiol. 1954 Jan;123(1):32-54. (PMID: 13131245)
    • Contributed Indexing:
      Keywords: HISTAMINASE/antagonists*; RAUWOLFIA/pharmacology*
    • Accession Number:
      0 (Alkaloids)
      0 (Guanidines)
      820484N8I3 (Histamine)
      EC 1.4.3.21 (Amine Oxidase (Copper-Containing))
      SCQ4EZQ113 (pimagedine)
    • Publication Date:
      Date Created: 19610401 Date Completed: 19981101 Latest Revision: 20190513
    • Publication Date:
      20221213
    • Accession Number:
      PMC1481958
    • Accession Number:
      10.1111/j.1476-5381.1961.tb00307.x
    • Accession Number:
      13745213