Tau tubulin kinases in proteinopathy.

A number of neurodegenerative diseases are characterized by deposition of abnormally phosphorylated tau or TDP‐43 in disease‐affected neurons. These diseases include Alzheimer's disease, frontotemporal lobar degeneration, and amyotrophic lateral sclerosis. No disease‐modifying therapeutics is available to treat these disorders, and we have a limited understanding of the cellular and molecular factors integral to disease initiation or progression. Phosphorylated tau and TDP‐43 are important markers of pathology in dementia disorders and directly contribute to tau‐ and TDP‐43‐related neurotoxicity and neurodegeneration. Here, we review the scope of tau and TDP‐43 phosphorylation in neurodegenerative disease and discuss recent work demonstrating the kinases TTBK1 and TTBK2 phosphorylate both tau and TDP‐43, promoting neurodegeneration. [ABSTRACT FROM AUTHOR]

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