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Topoisomerases of kinetoplastid parasites as potential chemotherapeutic targets
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- Author(s): Das, Aditi1; Dasgupta, Arindam2; Sengupta, Tanushri3; Majumder, Hemanta K.3
- Source:
Trends in Parasitology. Aug2004, Vol. 20 Issue 8, p381-387. 7p.- Subject Terms:
*PROTOZOA; *PARASITES; *TRYPANOSOMA; *LEISHMANIA; *CRITHIDIA; *KINETOPLASTIDA; *EUKARYOTIC cells; *DNA topoisomerases; *CYTOLOGY; *ENZYMES; *DNA; *GENES - Source:
- Additional Information
- Abstract: The protozoan parasites Trypanosoma, Leishmania and Crithidia, which belong to the order kinetoplastidae, emerge from the most ancient eukaryotic lineages. The diversity found in the life cycle of these organisms must be directed by genetic events, wherein topoisomerases play an important role in cellular processes affecting the topology and organization of intracellular DNA. Topoisomerases are valuable as potential drug targets because they have indispensable function in cell biology. This review summarizes what is known about topoisomerase genes and proteins of kinetoplastid parasites and the roles of these enzymes as targets for therapeutic agents. [Copyright &y& Elsevier]
- Abstract: Copyright of Trends in Parasitology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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