Ephestia: the experimental design of Alfred Kühn's physiological developmental genetics.

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  • Author(s): Rheinberger HJ;Rheinberger HJ
  • Source:
    Journal of the history of biology [J Hist Biol] 2000; Vol. 33 (3), pp. 535-76.
  • Publication Type:
    Biography; Historical Article; Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Springer Country of Publication: Germany NLM ID: 0202503 Publication Model: Print Cited Medium: Print ISSN: 0022-5010 (Print) Linking ISSN: 00225010 NLM ISO Abbreviation: J Hist Biol
    • Publication Information:
      Publication: 1998- : Heidelberg : Springer
      Original Publication: Cambridge, Belknap Press of Harvard Univ. Press.
    • Subject Terms:
      Research Design*; Genetics/*history ; Moths/*growth & development ; Moths/*physiology ; Physiology/*history; Animals ; Germany ; History, 20th Century
    • Subject Terms:
      Kuhn A
    • Abstract:
      Much of the early history of developmental and physiological genetics in Germany remains to be written. Together with Carl Correns and Richard Goldschmidt, Alfred Kühn occupies a special place in this history. Trained as a zoologist in Freiburg im Breisgau, he set out to integrate physiology, development and genetics in a particular experimental system based on the flour moth Ephestia kühniella Zeller. This paper is meant to reconstruct the crucial steps in the experimental pathway that led Kühn and his collaborators at the University of Göttingen, and later at the Kaiser Wilhelm Institutes of Biology and Biochemistry in Berlin, to formulate, in their specific way, what later became known as the "one gene - one enzyme hypothesis." Special attention will be given to the interaction of the different parts of Kühn's Ephestia-based project, which were rooted in different research traditions. The paper retraces how, roughly between 1925 and 1945, these elements came to form a mixed experimental set-up composed of genetic, embryological, physiological and, finally, biochemical constituents. Accordingly, emphasis is laid on the development of the terminology in which the results were cast, and how it reflected the hybrid state of an experimental system successively acquiring new epistemic layers.
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    • Publication Date:
      Date Created: 20030919 Date Completed: 20031001 Latest Revision: 20220716
    • Publication Date:
      20231215
    • Accession Number:
      10.1023/a:1004858314375
    • Accession Number:
      13678079