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Effects of MTHFR C677T and A1298C Polymorphisms on Migraine Susceptibility: A Meta‐Analysis of 26 Studies.
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- Author(s): Liu, Lijun; Yu, Yongpeng; He, Jian; Guo, Lei; Li, Hong; Teng, Jijun
- Source:
Headache: The Journal of Head & Face Pain. Jun2019, Vol. 59 Issue 6, p891-905. 15p. 1 Diagram, 3 Charts, 5 Graphs. - Source:
- Additional Information
- Subject Terms: MIGRAINE; MIGRAINE risk factors; ASIANS; CONFIDENCE intervals; DISEASE susceptibility; ETHNIC groups; GENETIC polymorphisms; INFORMATION storage & retrieval systems; MEDICAL databases; MEDICAL information storage & retrieval systems; MEDLINE; META-analysis; ONLINE information services; OXIDOREDUCTASES; WHITE people; SYSTEMATIC reviews; ODDS ratio; GENOTYPES; GENETICS
- Subject Terms:
- Abstract: Background: Multiple studies have evaluated the associations between 5,10‐methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and migraine risk with conflicting results. Therefore, we conducted a meta‐analysis on this theme. Methods: We searched the electronic databases of PubMed, EmBase, ScienceDirect, and Cochrane Library for all relevant studies published until April 6, 2018. Pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) in allelic, dominant, recessive, homozygous, and heterozygous models were calculated using random effects model to assess the strength of associations. We also performed subgroup analyses stratified by ethnicity and migraine subtypes, respectively. Results: Twenty‐six studies (20 in Caucasians, 3 in Asians, 2 in Indians, and 1 in Pakistanis) with 10,228 migraineurs and 28,608 controls were included in this meta‐analysis. In the overall population, the allele 677T and TT genotype were associated with an increased risk for total migraine and migraine with aura (MA) (total migraine: T vs C: OR = 1.19, 95%CI = 1.06‐1.33, P = .004; TT vs CC: OR = 1.32, 95%CI = 1.07‐1.64, P = .011; MA: T vs C: OR = 1.28, 95%CI = 1.09‐1.51, P = .003; TT vs CC: OR = 1.51, 95%CI = 1.09‐2.08, P = .012), but not for migraine without aura (MO). Subgroup analysis stratified by ethnicity revealed similar findings in Caucasians. In Asians, the association was detected only in recessive model in total migraine (TT vs CT + CC: OR = 1.80, 95%CI = 1.14‐2.85, P = .012). Results in Indians did not suggest any association in either total migraine or its subtypes. Pooled results of 5 studies (4 in Caucasians and 1 in Indians) on A1298C polymorphism indicated a significant association between the CC genotype and migraine risk (CC vs AA: OR = 1.78, 95%CI = 1.03‐3.07, P = .038), which only appeared for MO (CC vs AA: OR = 2.83, 95%CI = 1.30‐6.16, P = .009). Conclusions: Our meta‐analysis suggested that allele 677T in MTHFR C677T polymorphism might be a genetic risk factor for MA in Caucasians, and genotype 1298CC might contribute to MO susceptibility. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Headache: The Journal of Head & Face Pain is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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