Responses of limbic and extrapyramidal neurotensin systems to stimulants of abuse. Involvement of dopaminergic mechanisms.

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  • Additional Information
    • Source:
      Publisher: New York Academy of Sciences Country of Publication: United States NLM ID: 7506858 Publication Model: Print Cited Medium: Print ISSN: 0077-8923 (Print) Linking ISSN: 00778923 NLM ISO Abbreviation: Ann N Y Acad Sci Subsets: MEDLINE
    • Publication Information:
      Publication: 2006- : New York, NY : Malden, MA : New York Academy of Sciences ; Blackwell
      Original Publication: New York, The Academy.
    • Subject Terms:
      Cocaine/*pharmacology ; Dopamine/*metabolism ; Limbic System/*metabolism ; Methamphetamine/*pharmacology ; Neurotensin/*metabolism ; Phencyclidine/*pharmacology ; Pyramidal Tracts/*metabolism; Animals ; Dizocilpine Maleate/pharmacology ; Dopamine Agents/pharmacology ; Illicit Drugs/pharmacology ; Rats ; Receptors, Dopamine D1/metabolism ; Receptors, Dopamine D2/metabolism ; Receptors, N-Methyl-D-Aspartate/metabolism
    • Abstract:
      In summary, we have observed that drugs of abuse, which can cause schizophrenia-like paranoia, alter striatal and accumbens NT systems in a similar, dramatic fashion. The NT responses to these drugs, in particular METH, are mediated by activation of DA D1 receptors. We have observed that NMDA-type glutamate receptors are essential for the D1-NT interaction. NMDA receptors are selective, since they do not contribute to the antagonistic effects of DA D2 receptors on NT activity. This observation suggests that NT responses to D1 and D2 regulation are mediated through separate and distinct mechanisms. Finally, we found that the presence of METH dramatically reduces striatal NT release, which most likely leads to NT accumulation in nerve terminals and the observed increase in NT tissue level. The blockade of NT release by a psychotogenic drug, such as METH, is consistent with the hypothesis that NT has antipsychotic activity and a decrease in its release may contribute to some forms of schizophrenia similar to that caused by intense use of the stimulants of abuse.
    • Number of References:
      14
    • Accession Number:
      0 (Dopamine Agents)
      0 (Illicit Drugs)
      0 (Receptors, Dopamine D1)
      0 (Receptors, Dopamine D2)
      0 (Receptors, N-Methyl-D-Aspartate)
      39379-15-2 (Neurotensin)
      44RAL3456C (Methamphetamine)
      6LR8C1B66Q (Dizocilpine Maleate)
      I5Y540LHVR (Cocaine)
      J1DOI7UV76 (Phencyclidine)
      VTD58H1Z2X (Dopamine)
    • Publication Date:
      Date Created: 19920101 Date Completed: 19930113 Latest Revision: 20191210
    • Publication Date:
      20221208
    • Accession Number:
      10.1111/j.1749-6632.1992.tb27348.x
    • Accession Number:
      1361111