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Genome-wide association study reveals sex-specific genetic architecture of facial attractiveness.
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![loading](/sites/all/modules/hf_eds/images/loading.gif)
- Author(s): Hu, Bowen; Shen, Ning; Li, James J.; Kang, Hyunseung; Hong, Jinkuk; Fletcher, Jason; Greenberg, Jan; Mailick, Marsha R.; Lu, Qiongshi
- Source:
PLoS Genetics; 4/4/2019, Vol. 15 Issue 4, p1-18, 18p- Subject Terms:
- Source:
- Additional Information
- Abstract: Facial attractiveness is a complex human trait of great interest in both academia and industry. Literature on sociological and phenotypic factors associated with facial attractiveness is rich, but its genetic basis is poorly understood. In this paper, we conducted a genome-wide association study to discover genetic variants associated with facial attractiveness using 4,383 samples in the Wisconsin Longitudinal Study. We identified two genome-wide significant loci, highlighted a handful of candidate genes, and demonstrated enrichment for heritability in human tissues involved in reproduction and hormone synthesis. Additionally, facial attractiveness showed strong and negative genetic correlations with BMI in females and with blood lipids in males. Our analysis also suggested sex-specific selection pressure on variants associated with lower male attractiveness. These results revealed sex-specific genetic architecture of facial attractiveness and provided fundamental new insights into its genetic basis. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of PLoS Genetics is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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