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Folly Beach Library
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Edgar Allan Poe/Sullivan's Island Library
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Village Library
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Efficacy of intravenous ketamine treatment in anxious versus nonanxious unipolar treatment-resistant depression.
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- Author(s): Salloum, Naji C. (AUTHOR); Fava, Maurizio (AUTHOR); Freeman, Marlene P. (AUTHOR); Flynn, Martina (AUTHOR); Hoeppner, Bettina (AUTHOR); Hock, Rebecca S. (AUTHOR); Cusin, Cristina (AUTHOR); Iosifescu, Dan V. (AUTHOR); Trivedi, Madhukar H. (AUTHOR); Sanacora, Gerard (AUTHOR); Mathew, Sanjay J. (AUTHOR); Debattista, Charles (AUTHOR); Ionescu, Dawn F. (AUTHOR); Papakostas, George I. (AUTHOR)
- Source:
Depression & Anxiety (1091-4269). Mar2019, Vol. 36 Issue 3, p235-243. 9p. 3 Charts, 2 Graphs. - Source:
- Additional Information
- Subject Terms:
- Abstract:
Objective: To examine the effect of high baseline anxiety on response to ketamine versus midazolam (active placebo) in treatment-resistant depression (TRD).Methods: In a multisite, double-blind, placebo-controlled trial, 99 subjects with TRD were randomized to one of five arms: a single dose of intravenous ketamine 0.1, 0.2, 0.5, 1.0 mg/kg, or midazolam 0.045 mg/kg. The primary outcome measure was change in the six-item Hamilton Rating Scale for Depression (HAMD6). A linear mixed effects model was used to examine the effect of anxious depression baseline status (defined by a Hamilton Depression Rating Scale Anxiety-Somatization score ≥7) on response to ketamine versus midazolam at 1 and 3 days postinfusion.Results: N = 45 subjects had anxious TRD, compared to N = 54 subjects without high anxiety at baseline. No statistically significant interaction effect was found between treatment group assignment (combined ketamine treatment groups versus midazolam) and anxious/nonanxious status on HAMD6 score at either days 1 or 3 postinfusion (Day 1: F(1, 84) = 0.02, P = 0.88; Day 3: F(1, 82) = 0.12, P = 0.73).Conclusion: In contrast with what is observed with traditional antidepressants, response to ketamine may be similar in both anxious and nonanxious TRD subjects. These pilot results suggest the potential utility of ketamine in the treatment of anxious TRD. [ABSTRACT FROM AUTHOR] - Abstract: Copyright of Depression & Anxiety (1091-4269) is the property of Hindawi Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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