پلی مورفیسم های ژن موسینی نوع یک سلول T و ارتباط آنها با بیماری آرتریت روماتوئید (Persian)

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    • Alternate Title:
      Polymorphisms of T-cell immunoglobulin mucin Domain-1 Gene and its Association With rheumatoid arthritis. (English)
    • Abstract:
      Background: TIM-1, a member of the T cell immunoglobulin and mucin domain (TIM) gene family was implicated as a Rheumatoid arthritis susceptibility gene in previous studies. The aim of this study was to investigate the association of the genotype and allele frequencies of the TIM-1polymorphisms in patients with Rheumatoid arthritis. Methods: PCR-RFLP (Polymerase chain reaction–restriction fragment length polymorphism) & SSP-PCR (Single Specific Primer-Polymerase Chain Reaction) were used for investigating the presence of TIM-1 polymorphisms in 88 RA patients and 88 healthy controls. Results: The genotype and allele frequency of TIM-1 polymorphisms were significantly different between the patient and controls. Significant association was observed between this polymorphisms (GG and -1637A>G polymorphism of the Tim-1 might be associated with susceptibility to RA. [ABSTRACT FROM AUTHOR]
    • Abstract:
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