Measurement of Alpha-fetoprotein Levels in Patients with Chronic Hepatopathy.

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    • Subject Terms:
      ALPHA fetoproteins; LIVER cancer; LIVER diseases; GLYCOPROTEINS; BLOOD proteins; LIVER regeneration
    • Abstract:
      Introduction: Alpha-fetoprotein (AFP) is a glycoprotein associated with hepatic regeneration, as well as with neoplastic processes such as hepatocellular carcinoma (HCC). Nowadays, AFP is used as a criterion for HCC diagnosis, although it is not very sensitive and specific. Objective: The objective of this study was to evaluate the levels of AFP in patients with chronic hepatopathy. Materials and Methods: Patients with chronic hepatopathy and AFP were studied (January 2015-December 2017), including 160 patients. They were classified by etiology (primary biliary cholangitis, HCC, non-alcoholic steatohepatitis, autoimmune hepatitis, alcoholic hepatitis, hepatitis B, hepatitis C, and liver disease of an indeterminate origin). Results: A significant difference was observed between the group of patients with HCC and the other study groups, presenting AFP levels above the reference limit. The other groups showed normal values. Conclusion: Patients with HCC showed high levels of AFP, but not patients with the other hepatopathies studied. [ABSTRACT FROM AUTHOR]
    • Abstract:
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