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FIRSTT study: randomized controlled trial of uterine artery embolization vs focused ultrasound surgery.
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- Author(s): Laughlin-Tommaso, Shannon (AUTHOR); Barnard, Emily P. (AUTHOR); AbdElmagied, Ahmed M. (AUTHOR); Vaughan, Lisa E. (AUTHOR); Weaver, Amy L. (AUTHOR); Hesley, Gina K. (AUTHOR); Woodrum, David A. (AUTHOR); Jacoby, Vanessa L. (AUTHOR); Kohi, Maureen P. (AUTHOR); Price, Thomas M. (AUTHOR); Nieves, Angel (AUTHOR); Miller, Michael J. (AUTHOR); Borah, Bijan J. (AUTHOR); Moriarty, James P. (AUTHOR); Gorny, Krzysztof R. (AUTHOR); Leppert, Phyllis C. (AUTHOR); Severson, Amanda L. (AUTHOR); Lemens, Maureen A. (AUTHOR); Stewart, Elizabeth A. (AUTHOR)
- Source:
American Journal of Obstetrics & Gynecology. Feb2019, Vol. 220 Issue 2, p174.e1-174.e13. 1p. - Source:
- Additional Information
- Subject Terms: UTERINE artery; ULTRASONIC imaging; UTERINE tumors; CLINICAL trial registries; UTERINE fibroids; OVARIAN reserve; UTERINE surgery; COMPARATIVE studies; LONGITUDINAL method; MAGNETIC resonance imaging; RESEARCH methodology; MEDICAL cooperation; RESEARCH; RESEARCH funding; ULTRASONIC therapy; THERAPEUTIC embolization; EVALUATION research; RANDOMIZED controlled trials; TREATMENT effectiveness
- Subject Terms:
- Abstract:
Background: Uterine leiomyomas (fibroid tumors) cause considerable symptoms in 30-50% of women and are the leading cause of hysterectomy in the United States. Women with uterine fibroid tumors often seek uterine-preserving treatments, but comparative effectiveness trials are lacking.Objective: The purpose of this study was to report treatment effectiveness and ovarian function after uterine artery embolization vs magnetic resonance imaging-guided focused ultrasound surgery from the Fibroid Interventions: Reducing Symptoms Today and Tomorrow study.Study Design: The Fibroid Interventions: Reducing Symptoms Today and Tomorrow study, which is a randomized controlled trial of uterine artery embolization vs magnetic resonance imaging-guided focused ultrasound surgery, enrolled premenopausal women with symptomatic uterine fibroid tumors; women who declined randomization were enrolled in a parallel observational cohort. A comprehensive cohort design was used for outcomes analysis. Our target enrollment was 220 women, of which we achieved 41% (n=91) in the randomized and parallel arms of the trial. Primary outcome was reintervention for uterine fibroid tumors within 36 months. Secondary outcomes were change in serum anti-Müllerian hormone levels and standardized measures of fibroid symptoms, quality of life, pain, and sexual function.Results: From 2010-2014, 83 women (mean age, 44.4 years) were treated in the comprehensive cohort design (43 for magnetic resonance imaging-guided focused ultrasound surgery [27 randomized]; 40 for uterine artery embolization [22 randomized]); baseline clinical and uterine characteristics were similar between treatment arms, except for higher fibroid load in the uterine artery embolization arm. The risk of reintervention was higher with magnetic resonance imaging-guided focused ultrasound surgery than uterine artery embolization (hazard ratio, 2.81; 95% confidence interval, 1.01-7.79). Uterine artery embolization showed a significantly greater absolute decrease in anti-Müllerian hormone levels at 24 months compared with magnetic resonance imaging-guided focused ultrasound surgery. Quality of life and pain scores improved in both arms but to a greater extent in the uterine artery embolization arm. Higher pretreatment anti-Müllerian hormone level and younger age at treatment increased the overall risk of reintervention.Conclusion: Our study demonstrates a lower reintervention rate and greater improvement in symptoms after uterine artery embolization, although some of the effectiveness may come through impairment of ovarian reserve. Both pretreatment anti-Müllerian hormone level and age are associated with risk of reintervention.Clinical Trial Registration Number: NCT00995878, clinicaltrials.gov. [ABSTRACT FROM AUTHOR] - Abstract: Copyright of American Journal of Obstetrics & Gynecology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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