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West Ashley Library
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Phone: (843) 766-6635
Folly Beach Library
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Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
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Wando Mount Pleasant Library
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Phone: (843) 805-6888
Village Library
9 a.m. - 1 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
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Otranto Road Library
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Mt. Pleasant Library
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McClellanville Library
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Keith Summey North Charleston Library
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John's Island Library
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Hurd/St. Andrews Library
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Miss Jane's Building (Edisto Library Temporary Location)
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Dorchester Road Library
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John L. Dart Library
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Baxter-Patrick James Island
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Phone: (843) 795-6679
Main Library
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Phone: (843) 805-6930
Bees Ferry West Ashley Library
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Phone: (843) 805-6892
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Phone: (843) 805-6909
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Preferential expression of IL-2 receptor subunits on memory populations within CD4+ and CD8+ T cells.
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- Author(s): Taga, K.1; Kasahara, Y.1; Yachie, A.1; Miyawaki, T.1; Taniguchi, N.1
- Source:
Immunology. Jan1991, Vol. 72 Issue 1, p15-19. 5p. - Source:
- Additional Information
- Subject Terms:
- Abstract: Using anti-Tac and anti-Mik-β1 monoclonal antibodies to α and β subunits of the interleukin-2 receptor (IL-2R), respectively, a marked difference in expression of IL-2R subunits on blood CD4+ and CD8+ T cells was demonstrated between adults and newborns. In the adult blood, reciprocal expression of IL-2Rα and IL-2Rβ was observed in CD4+ and CD8+ T cells. Some CD4+ T cells expressing IL-2Rα were often detected, but IL=2Rβ+ CD4+ cells were very few. On the other hand, CD8+ T cells expressed significant IL-2Rβ but little IL-2Rα. In marked contrast to adult individuals, both CD4+ and CD8+ T cells from the newborns, which seemed to consist mainly of naive populations, showed only negligible expression of IL=2R subunits, it was found that IL-2R subunits appeared to be preferentially expressed on CD4 + and CD8+ T cells with memory phenotypes in the adult blood. Isolated memory (CD45RO+) CD4+ and CD8+ T cells, unlike naive (CD45RO-) ones, were able to proliferate in response to exogenous IL-2 as well as the recall antigen. The present results suggest that IL-2R subunits expressed on circulating T-cell subsets may play an important role in memory T-cell function. [ABSTRACT FROM AUTHOR]
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