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Lymphocytic esophagitis: an update on histologic diagnosis, endoscopic findings, and natural history.
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- Author(s): Patil, Deepa T.; Hammer, Suntrea; Langer, Rupert; Yantiss, Rhonda K.
- Source:
Annals of the New York Academy of Sciences; Dec2018, Vol. 1434 Issue 1, p185-191, 7p, 1 Color Photograph, 2 Charts- Subject Terms:
- Source:
- Additional Information
- Abstract: Lymphocytic esophagitis is a histologic pattern of injury characterized by increased intraepithelial lymphocytes (>20/high‐power field) with rare, or absent granulocytes. Lymphocytes tend to be more numerous in the peripapillary epithelium, and are often associated with evidence of mucosal injury, edema, and scattered dyskeratotic cells. More than a decade following its original description, lymphocytic esophagitis remains an enigmatic entity with variable clinical presentations, associated disorders, etiologies, treatment, and natural history. Most of the confusion regarding the clinical significance of this disorder stems from its diagnostic criteria: lymphocytic esophagitis is currently defined based entirely on histologic criteria, despite the common occurrence of lymphocytosis in a variety of unrelated inflammatory conditions of the esophagus. The goal of this review is to summarize the literature regarding lymphocytic esophagitis and focus on key clinicopathologic features that distinguish it from other esophageal disorders that can show increased numbers of intraepithelial lymphocytes. Lymphocytic esophagitis is a histologic pattern of injury characterized by increased intraepithelial lymphocytes, with rare or absent granulocytes. The goal of this review is to summarize the literature regarding lymphocytic esophagitis and focus on key clinicopathologic features that distinguish it from other esophageal disorders that can show increased numbers of intraepithelial lymphocytes. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Annals of the New York Academy of Sciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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