The Immune Response to Influenza Virus I. EFFECT OF THE ROUTE AND SCHEDULE OF VACCINATION ON THE TIME COURSE OF THE IMMUNE RESPONSE, AS MEASURED BY THREE SEROLOGICAL METHODS.

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    • Abstract:
      The influence of the route and schedule of vaccination on the time course of the immune response was studied in groups of rabbits injected influenza virus antigens. The route and schedule of inoculation determined the maximal level of serum antibody. The routes can be ordered intravenous, intraperitoneal and subcutaneous in descending order of efficiency. Multiple doses improved the levels of antibody by all routes, while antigen in Freund's incomplete adjuvant suppressed the initial response. Changes in the ratios between the three tests indicated differences in avidity of antibody produced during the initial and the secondary responses. [ABSTRACT FROM AUTHOR]
    • Abstract:
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