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Implementation and validation of constitutive relations for human dermis mechanical response.
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- Author(s): Aldieri, Alessandra; Terzini, Mara; Bignardi, Cristina; Zanetti, Elisabetta M.; Audenino, Alberto L.
- Source:
Medical & Biological Engineering & Computing. Nov2018, Vol. 56 Issue 11, p2083-2093. 11p. 1 Color Photograph, 1 Black and White Photograph, 2 Charts, 4 Graphs. - Source:
- Additional Information
- Subject Terms:
- Abstract: Finite element models in conjunction with adequate constitutive relations are pivotal in several physiological and medical applications related to both native and engineered tissues, allowing to predict the tissue response under various loading states. In order to get reliable results, however, the validation of the constitutive models is crucial. Therefore, the main purpose of this work is to provide an experimental-computational approach to the biomechanical investigation of soft tissues such as the dermis. This is accomplished by implementing and validating three widely adopted hyperelastic constitutive models (the Ogden, the Holzapfel, and the Gasser-Ogden-Holzapfel laws) supposed to be adequate to reproduce human reticular dermis mechanical behavior. Biaxial experimental data have represented the basis for the determination of the respective material parameters identified thanks to the definition of a cost function accounting for the discrepancy between experimental and predicted data. Afterwards, the experimental tests have been reproduced through finite element simulations. Hence, the constitutive laws have been validated comparing experimental and numerical outcomes in terms of displacements of four reference points and stress-strain relations. Hence, an experimental-numerical framework is proposed for the investigation of collagenous tissues, which could become more accurate with larger and independent experimental datasets. Graphical abstract ᅟ. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Medical & Biological Engineering & Computing is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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